ID   CWC22_CANAL             Reviewed;         648 AA.
AC   Q59XY0; A0A1D8PIM7; Q59XT4;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22;
GN   Name=CWC22; OrderedLocusNames=CAALFM_C210100WA;
GN   ORFNames=CaO19.1771, CaO19.9340;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27987.1; -; Genomic_DNA.
DR   RefSeq; XP_714416.2; XM_709323.2.
DR   AlphaFoldDB; Q59XY0; -.
DR   SMR; Q59XY0; -.
DR   STRING; 237561.Q59XY0; -.
DR   PRIDE; Q59XY0; -.
DR   GeneID; 3643938; -.
DR   KEGG; cal:CAALFM_C210100WA; -.
DR   CGD; CAL0000192468; CWC22.
DR   VEuPathDB; FungiDB:C2_10100W_A; -.
DR   eggNOG; KOG2140; Eukaryota.
DR   HOGENOM; CLU_006308_3_4_1; -.
DR   InParanoid; Q59XY0; -.
DR   OrthoDB; 996017at2759; -.
DR   PRO; PR:Q59XY0; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02847; MA3; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..648
FT                   /note="Pre-mRNA-splicing factor CWC22"
FT                   /id="PRO_0000215669"
FT   DOMAIN          29..237
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   DOMAIN          328..460
FT                   /note="MI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   REGION          548..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        548..562
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        606..626
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        627..648
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   648 AA;  75201 MW;  C418F2662B87F0C1 CRC64;
     MENSTTTTTT TTVTQPDESY QRTKWIETKK NIKQLLQQLT PSNIKQTVLQ LFQINLLRYQ
     GLFIREIMKQ QIRITTNAEL YGSLISIINS KIPEIGELLI NRLVLQFKKN YLQNNKNLIN
     SSIIFICQLI NQQVLNEILI LQILQMLLES NVPNNNNNNN NNNIELAIMV LKQTGSYLFK
     HSNTALIMIL NRLKDILQDG ANANANGGNG GVGLSSWNRK SIEYILKLAR NDFKNISIIK
     NGLDLVETED KETHVITLED KLYSRDHLNV FSVDEEYLDH ENEYIELKKE ILGETDHEDE
     NENEIQVIET TKNYEEKITD MSQSELLQYQ KTVYLTIMSS MSSDEAVHKL LKLNFKSKIK
     NKTKNKTKTK TNSNDNEILA DMVIKCCSQE KTYSKYYGII GEKLISRNDH WHNLFIKLFK
     YYYDIIENFE TNSLRNLGKF FGHLFASDKL ALDQAWSNIK LTEQDTNPAK RILLKFIFQE
     MIEELGINEV KERLINDDYL KPYIKGIFPV INVDGKDADA IRFSINFFTA IGLGVLTEEM
     RYVLDNLSEP EEEDDRGRSR SRSYSRSASS SSYNSRSRSY SRSQSRSSRS PNPRGRQRFK
     TKKHNHNESR TPSRENLKRK RSESVTDRNG NNNNNNNNNL QDLLNNLK