CWC22_CRYNJ
ID CWC22_CRYNJ Reviewed; 831 AA.
AC P0CM96; Q55Q93; Q5KFX4;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=Pre-mRNA-splicing factor CWC22;
GN Name=CWC22; OrderedLocusNames=CNF00260;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR EMBL; AE017346; AAW44142.1; -; Genomic_DNA.
DR RefSeq; XP_571449.1; XM_571449.1.
DR AlphaFoldDB; P0CM96; -.
DR SMR; P0CM96; -.
DR STRING; 5207.AAW44142; -.
DR PaxDb; P0CM96; -.
DR PRIDE; P0CM96; -.
DR EnsemblFungi; AAW44142; AAW44142; CNF00260.
DR GeneID; 3258354; -.
DR KEGG; cne:CNF00260; -.
DR VEuPathDB; FungiDB:CNF00260; -.
DR eggNOG; KOG2140; Eukaryota.
DR HOGENOM; CLU_006308_0_0_1; -.
DR InParanoid; P0CM96; -.
DR OMA; NIFKFDA; -.
DR OrthoDB; 996017at2759; -.
DR Proteomes; UP000002149; Chromosome 6.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..831
FT /note="Pre-mRNA-splicing factor CWC22"
FT /id="PRO_0000215670"
FT DOMAIN 174..357
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 460..576
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 94662 MW; 30D8D934AA0A0C8E CRC64;
MPRSLSRSVS PRPRSPSLSP PRPDSRSSRG RSLTPDDIPA YKRKRSPSPN PRDRPASPPT
RRRRSQSPYR NSNRAEIDRP NVKDIDPNRR RARENALLEK QINMALADDG DADGTVATTK
KSADEIARAE FAKLLGSRSG GAYIPPAKLR AMQAEAAKDK TSAEYQRISW DALKKSINGL
INKVNISNIK HIVPELFGEN LIRGRGLFAR SVMRAQASSL PFTPVFAALV AIINTKLPQV
GELVLIRLIS QFRRAYKRND KTVCHATSTF IAHLCNQYVA HEIVALQILL LCLDRPTDDS
IEVAVGFMRE VGQFLSENSP KANNTVFERF RAVLHEGQIS KRCQYMIEVL FQVRKDKYKD
NPAVPEGLDL VEEEEQITHR VTLDDELQVQ ESLNLFKADP NFVQNEERYN AIKREILGDS
DDESGTESGS EYSESEDDED EDVAPEKAGI QDMTETNLIN LRRTIYLTIM NSLNFEEAVH
KLMKVNIPEG REIELCNMVI ECCSQERTYS NFYGLIGERF CKLHRIWTDA FQEAFQKYYD
TIHRYETNKL RNIGRFFGHL LASDGISWAV LHVVHMNEEE TTSSSRIFVK IVLQEMVEEM
GINRVAERFR IPDLKPAFAG MFPMDNPKNA RFSINYFTSI GMGKVTEDMR EYLQNAPKLL
AAQQAALAAA ESSDSDTDSS SDISSSSDSD SDTDSDASSY SRRSRRRRYS SDSRSPPPRR
RRYSSDSRSP SPPPRRRQYS DEPRSPSPPP RRRRYSDDSR SPSPPPRRRY SGDSRSPSPP
PRRRYADDSR SPSPPPHRRR YSDDSRSPSP PPRRRRYSDN SRSPSPPPRR R
