ID   CWC22_DEBHA             Reviewed;         637 AA.
AC   Q6BU84;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22;
GN   Name=CWC22; OrderedLocusNames=DEHA2C12870g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR   EMBL; CR382135; CAG86311.2; -; Genomic_DNA.
DR   RefSeq; XP_458235.2; XM_458235.1.
DR   AlphaFoldDB; Q6BU84; -.
DR   SMR; Q6BU84; -.
DR   STRING; 4959.XP_458235.2; -.
DR   EnsemblFungi; CAG86311; CAG86311; DEHA2C12870g.
DR   GeneID; 2900736; -.
DR   KEGG; dha:DEHA2C12870g; -.
DR   VEuPathDB; FungiDB:DEHA2C12870g; -.
DR   eggNOG; KOG2140; Eukaryota.
DR   HOGENOM; CLU_006308_3_4_1; -.
DR   InParanoid; Q6BU84; -.
DR   OMA; NIFKFDA; -.
DR   OrthoDB; 996017at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   Pfam; PF02847; MA3; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..637
FT                   /note="Pre-mRNA-splicing factor CWC22"
FT                   /id="PRO_0000215671"
FT   DOMAIN          53..236
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   DOMAIN          331..453
FT                   /note="MI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT   REGION          538..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..578
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..593
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..608
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        610..630
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   637 AA;  73844 MW;  7ECD296BD8FA2566 CRC64;
     MSNNSAEYKE LLDLKSSGKY VPPAKLKALQ TKINNSSEST TEEYQVLQWE QLKRAINRQV
     NKCNVSNIRE IVVELFKLNL QRGKGLLIRS IMKAQLTDLI FTPIYASLIA VLNSKIPEVG
     ELILNRLLLQ FRKNYIKNKK NCISSAIFIV HLINQRVCSE ILILQILQLL LENPTNDSIE
     ICVEIMNQVG KYLQENSVAA NNMIFNRLRS ILHENEDIND RSQFLIENLF KTRKNGYSEY
     PIIRKELDLV DLDDQETHLL ELDAKVKSND QLNIFQFDEQ YDENEKLYDN VRKDILGDSD
     EEDDESEAEE SEEDNKEILE IKDMTESNLL NYQKTVYLTV MSSMSSDEAV HKLIKLNFKK
     SNEEKYKNNE ILVDMIIKCC SQEKTYSKYY GVIGEKLCSM NKSWHTIFID TFKKYYSTIH
     QFETNSLRNI GKFFGHLFAS DKLAIERSWN VIRLTEEETN SASRIFIKFI FQEMIEEIGI
     KGLQERLDDD LIRQETNGLF PRQGVTYRNA EDIRFSINFF TAIGLGILTE EMRDVLKNLP
     PEERGRSRSV SGSSRSGSSS YSRSRSYSRS SGSYSRSRSR SRSRSRSRSR TGSRGRTMSR
     DRSKSFSRSR STSRSRGESF SRSPSRLPTG SKRFKPN