CWC22_EMENI
ID CWC22_EMENI Reviewed; 868 AA.
AC Q5BGP1; C8VUB2;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Pre-mRNA-splicing factor cwc22;
GN Name=cwc22; ORFNames=AN0289;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF89802.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAA66162.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA66162.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AACD01000005; EAA66162.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001308; CBF89802.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_657893.1; XM_652801.1.
DR AlphaFoldDB; Q5BGP1; -.
DR SMR; Q5BGP1; -.
DR STRING; 162425.CADANIAP00002431; -.
DR EnsemblFungi; EAA66162; EAA66162; AN0289.2.
DR GeneID; 2876063; -.
DR KEGG; ani:AN0289.2; -.
DR eggNOG; KOG2140; Eukaryota.
DR HOGENOM; CLU_006308_3_0_1; -.
DR InParanoid; Q5BGP1; -.
DR OrthoDB; 996017at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..868
FT /note="Pre-mRNA-splicing factor cwc22"
FT /id="PRO_0000215672"
FT DOMAIN 145..328
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 427..543
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..413
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 868 AA; 99226 MW; AAF009F7CE4EF1CD CRC64;
MSDSVVLQSA VRVPTPPPGA SYSPQPSGSR KRSPPSRSPS PNRRRSPPGD TADADRDVPR
IDPERAIERE RQLAERVRQY EQQEAARKPL TEEEKQAAAK AEYEKLLNMR SGGTYIPPAR
LRALQAQITD KTSKEYQRMA WEALKKSING LINKVNVSNI KYIVPELFGE NLVRGRGLFC
RSIMKAQAAS LPFTPIYAAM AAIVNTKLPQ VGELLLSRLI IQFRKAFKRN DKAVCISSTT
FIAHLCNQQV VHEMLAAQIL LLLLHKPTDD SVEIAVGLTR EVGQHLEEMS GPIALAVFDQ
FRNILHEADI DKRVQYMIEV LFQVRKDRYK DNPAIKEELD LVEEEDQITH RIGLDDEIET
QDGLNIFKYD PQWEEHEEAY KKLKAEILGE GSDDEDESGE DDESSDEESE EERQMDIKDQ
SNTDLVNLRR TIYLTIMSSI DFEECCHKLM KISLPAGLEP ELPSMIIECC SQERTYSKFY
GLIGERFAKI NRLWSDLFEN AFAKYYDTIH RYETNRLRNI ARFFGHMLST DALGWHVLSV
IHLNEEETTS SSRIFIKILF QDLAEHLGLP KLRERMTDEL LRPSFEGLFP TDNPRNTRFS
INYFTSIGFG VLTEELREFL KNMPKPEVPA LPPARSPSVS SRSSYSSRSR SSSYSYSRSP
SYSRSPSRSR SRRRSISRGR SYSRSVSGSS RRSYTRSSYT PSRSRSPAPR SRRRSVSYSR
SLSRSRSSPR RTRRGRTDSR SPPPRRSLSR SVSRSLTPPR RGGRARSYSR SPSRSLSRSV
SPPPRRASAR RRYSSESISP PGRARRSIPG SRSPRRPPPS RRARNYSVSR SPSPRYGRNQ
RRRNSSPSRS PSPPPRRRPR SPSTPPRR
