CWC22_USTMA
ID CWC22_USTMA Reviewed; 886 AA.
AC Q4PCY0; A0A0D1DZQ0;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 2.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Pre-mRNA-splicing factor CWC22;
GN Name=CWC22; ORFNames=UMAG_11905;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR EMBL; CM003144; KIS69494.1; -; Genomic_DNA.
DR RefSeq; XP_011388885.1; XM_011390583.1.
DR AlphaFoldDB; Q4PCY0; -.
DR SMR; Q4PCY0; -.
DR STRING; 5270.UM02033P0; -.
DR PRIDE; Q4PCY0; -.
DR EnsemblFungi; KIS69494; KIS69494; UMAG_11905.
DR GeneID; 23567716; -.
DR KEGG; uma:UMAG_11905; -.
DR VEuPathDB; FungiDB:UMAG_11905; -.
DR eggNOG; KOG2140; Eukaryota.
DR HOGENOM; CLU_006308_3_2_1; -.
DR InParanoid; Q4PCY0; -.
DR OrthoDB; 996017at2759; -.
DR Proteomes; UP000000561; Chromosome 5.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..886
FT /note="Pre-mRNA-splicing factor CWC22"
FT /id="PRO_0000215676"
FT DOMAIN 158..342
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 454..570
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..752
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..837
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 99748 MW; 37C0399CA6046323 CRC64;
MPSRERSPSS GLGFQSDSSR SSPPDAGVTA HKRKRSPTRS VSSRSTSSRS PSRSRSPPPR
SRRRRRSSRD RSQSSNSDES TEERKNTTRA REALEQNAKT LEIAAKGEAL RSTLAQLSAT
KSGGAYVPPA RLKALMAEAA AADPGSVEYQ RMSWDALKKS ITGLVNKVAV ENIKSIVPEL
FGGANLIRGR GLYCRSIMRA QALSLSFTPV FAALTAIVNT KLPMIGELLA VRLVSQFRRS
FKRNDKAVCN STAMFLAHLV NQRVVHEVLA LEILVLLLEK PTDDSVEIAV GFMREVGAFL
TEEAPKANNS IFDRFRAVLY EGEISKRVQY MIEVLSQVRR EGFKENPRIP DALDLVEEDD
QITHRISLDD QLNIEEGLNV FKMDPEFVEN EERYRSIKAE ILGENSDSDK TGSEADSESG
SSSDDSSDDE AGEGPDDAQR QLEIHDRTET NLINLRRTIY LTIMSSLDFE ESVHKLLKLE
VPEGQDIELC NMIVECCSQE RTYSKFYGNM GERFCKLHRK WADTFAQSFS NYYDTIHRYE
TNRLRNIARF FGHLFSTDSI SWASMSVIHM NEEDTTSSSR IFVKIMFQEM QQQLGLKELA
ERFKEPSLQE NWKGLFPTDN PKSTRFSINY FTSIGLGVLT EEMREYLKNA PKLLLAQRQA
ALAARGSDNS DSDSSSVLSS STGSRSRTSY SSYSRSSRSY SSGSGSYSSR SRSSRSYSSR
SYSSRSYSSR SRSRSRSRSR SRSRSRSRSR SRSRSRSPSE HQRHGRRRAR SASYSSYSSR
SRSSSSSSSR SRSRSRSRSR SFSRSLTPRG SYSRSCSRSP VPRRRAPRSR SRSADPRKRS
SRRSPSVSSY SGSETDDSIS RSPSPRAGYV DRRSHRHSRS ASPARR
