CWC22_YARLI
ID CWC22_YARLI Reviewed; 954 AA.
AC Q6C8C5;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pre-mRNA-splicing factor CWC22;
GN Name=CWC22; OrderedLocusNames=YALI0D20790g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC22 family. {ECO:0000305}.
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DR EMBL; CR382130; CAG81279.1; -; Genomic_DNA.
DR RefSeq; XP_503087.1; XM_503087.1.
DR AlphaFoldDB; Q6C8C5; -.
DR SMR; Q6C8C5; -.
DR STRING; 4952.CAG81279; -.
DR EnsemblFungi; CAG81279; CAG81279; YALI0_D20790g.
DR GeneID; 2911250; -.
DR KEGG; yli:YALI0D20790g; -.
DR VEuPathDB; FungiDB:YALI0_D20790g; -.
DR HOGENOM; CLU_006308_0_2_1; -.
DR InParanoid; Q6C8C5; -.
DR OMA; NIFKFDA; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51366; MI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..954
FT /note="Pre-mRNA-splicing factor CWC22"
FT /id="PRO_0000215677"
FT DOMAIN 224..407
FT /note="MIF4G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT DOMAIN 515..648
FT /note="MI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00698"
FT REGION 1..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..79
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..498
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..832
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..875
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..929
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 110337 MW; 817D10E6D016D294 CRC64;
MSDKERERER SQSRERSRTR ERSRTRDSKR DHSDSRSLRR RSYRGDRSRS PSRSRSRSYS
PSRSPRRKRR RHRTSRRSRR SRREGDGRRK DGPRGHDDRS PLAPREVEDV TVKREDSTND
KESTHDKEST NDKERNVSME DRKDTSEDVV EDVEEGDPSE EALEKKVKNP EDDLEAAAEE
LKKLMELKSG GRYVPPAKIR ALQKLLVQDK TSKEFQKIQF DNLKKAINSL VNKVSAQNIR
DIAGEIFTHN LIRGRGLFCR SVMTAQSLAL PYTPVYACLT AIVNSKLPQV GELLVRRLIL
QFRRGYKRNQ KDVCLSSVTF LAHLCNYHVA HEVLVLQLLH LLLETPTDHS VEVAVAFIKE
SGAFLAEVSP AANNGVFERL RAVLHDGELE KRTQYMIETL FQIRKDGYEN YPVVQEELDL
VDEEDYVTHM TGLDDKFTDD KLLNYFVMDP DYEANEEKYD LLKKEILGDS DDEEEDDSEA
EEEADDEEEE EGDEEEEAQA STSAVRDLTG TELATLRKKI YLTVMSTMSI DEIVHKLVKL
SRTVIEIPEG LPEDQALILR LKRTQEVTNM LVECCAQEKI YNKIYGGTGE RLLRLSREWR
TNFENTFGFF YSVIHRYEPN QIRNIATFFG YLLASDSLSW KVLEAVSLTE EDSNPSNRIF
LKIMFTEMRQ ELGMDLLKER LSKPFVQQYI AGMFPKTNAS HVRFAINYFT AINLGPLTDG
MREILPGLVE EEERLKKEEE EQKREYDSYD SYDSYDSYDS YDSYDSYDSY DSYDSYDSYD
SYDSYDSYDS YDSVSEDDRG RRRRRGVGSR RRSLTRSPGS RSRPRSRPRS RSRSRSLSRD
RTGSPPRGRR RSRSYSRSPS RSYSRSRSYS RSPSPRPKSK GAKGRSSYRA ASYSRSRSPV
RRVGYSRSRS PSVSGGSSRS PSRSPCRSPN KGRAPTPEKG LSPPRKRVRA SDLF
