ID   CWC23_CANGA             Reviewed;         296 AA.
AC   Q6FQ33;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Pre-mRNA-splicing factor CWC23;
GN   Name=CWC23; OrderedLocusNames=CAGL0I09526g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. May be involved in endoplasmic
CC       reticulum-associated protein degradation (ERAD) and required for growth
CC       at low and high temperatures (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DnaJ family. {ECO:0000305}.
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DR   EMBL; CR380955; CAG60598.1; -; Genomic_DNA.
DR   RefSeq; XP_447661.1; XM_447661.1.
DR   AlphaFoldDB; Q6FQ33; -.
DR   STRING; 5478.XP_447661.1; -.
DR   EnsemblFungi; CAG60598; CAG60598; CAGL0I09526g.
DR   GeneID; 2888934; -.
DR   KEGG; cgr:CAGL0I09526g; -.
DR   CGD; CAL0132576; CAGL0I09526g.
DR   VEuPathDB; FungiDB:CAGL0I09526g; -.
DR   eggNOG; KOG0716; Eukaryota.
DR   HOGENOM; CLU_063717_0_0_1; -.
DR   InParanoid; Q6FQ33; -.
DR   OMA; KHFKLPY; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; -; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; SSF46565; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..296
FT                   /note="Pre-mRNA-splicing factor CWC23"
FT                   /id="PRO_0000071126"
FT   DOMAIN          14..86
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
SQ   SEQUENCE   296 AA;  34399 MW;  ABBD481E21985DF0 CRC64;
     MSDVVKTVIG QRLDLYKLLE LNYKDYKGND DAATTHSLKK QYRKLSLRYH PDKNPGPEYI
     DRFHLLNLAI TVLADPAKKA EYDQWVAQYL YPDNGLSEAE QTRREALVQK LNASERKVRE
     DNQGGNVADI GKIQNYGEKL RRMAHFGLGF GDWRNLDEHI SRATTNTIED STTDKEVCTL
     RAVFDFQSIE NISDPNNLRR YMNEVFPEYM YDIDEIRYSS NNVYDGEEDI VVYIVLKDPI
     KTGRLYHQIK RNPPDAFVEI EPYISPKLFE SFSKEIPLND HVKNLLRGVP EVIDLD