ID   CWC24_CANAL             Reviewed;         216 AA.
AC   Q5ACW2; A0A1D8PG25;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 2.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Pre-mRNA-splicing factor CWC24;
GN   Name=CWC24; OrderedLocusNames=CAALFM_C200280CA;
GN   ORFNames=CaO19.2105, CaO19.9653;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC24 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27082.1; -; Genomic_DNA.
DR   RefSeq; XP_719551.2; XM_714458.2.
DR   AlphaFoldDB; Q5ACW2; -.
DR   SMR; Q5ACW2; -.
DR   BioGRID; 1221807; 1.
DR   STRING; 237561.Q5ACW2; -.
DR   PRIDE; Q5ACW2; -.
DR   GeneID; 3638802; -.
DR   KEGG; cal:CAALFM_C200280CA; -.
DR   CGD; CAL0000187163; orf19.9653.
DR   VEuPathDB; FungiDB:C2_00280C_A; -.
DR   eggNOG; KOG1813; Eukaryota.
DR   HOGENOM; CLU_050460_3_0_1; -.
DR   InParanoid; Q5ACW2; -.
DR   OrthoDB; 1420266at2759; -.
DR   PRO; PR:Q5ACW2; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034247; P:snoRNA splicing; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039971; CWC24-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12930; PTHR12930; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..216
FT                   /note="Pre-mRNA-splicing factor CWC24"
FT                   /id="PRO_0000055885"
FT   ZN_FING         98..126
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         156..196
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          19..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          43..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   216 AA;  24232 MW;  CC2A2DEFDE9D1EC8 CRC64;
     MFKKRVIKDS RVSKRKIGDI NEASEDAPDT QVTKKSTLIT KKSDIQKKSV VMPRSSPQTP
     LSKSSSDDAA AVEVVSQKSK KGELKPLAAN IKTTIITDFQ PDVCKDFQQT GYCGYGDTCK
     FLHVRDESRQ KIPIKKDWEI GGQKEVKEKE DIPFKCVLCK SDYKSPIKTE CGHIFCKACF
     LDRYKAKKKG TCFICHKETN GTMVPVNIDK LSATQV