ID   CWC24_CANGA             Reviewed;         226 AA.
AC   Q6FXX1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Pre-mRNA-splicing factor CWC24;
GN   Name=CWC24; OrderedLocusNames=CAGL0A00935g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC24 family. {ECO:0000305}.
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DR   EMBL; CR380947; CAG57702.1; -; Genomic_DNA.
DR   RefSeq; XP_444811.1; XM_444811.1.
DR   AlphaFoldDB; Q6FXX1; -.
DR   SMR; Q6FXX1; -.
DR   STRING; 5478.XP_444811.1; -.
DR   EnsemblFungi; CAG57702; CAG57702; CAGL0A00935g.
DR   GeneID; 2886435; -.
DR   KEGG; cgr:CAGL0A00935g; -.
DR   CGD; CAL0126671; CAGL0A00935g.
DR   VEuPathDB; FungiDB:CAGL0A00935g; -.
DR   eggNOG; KOG1813; Eukaryota.
DR   HOGENOM; CLU_050460_3_0_1; -.
DR   InParanoid; Q6FXX1; -.
DR   Proteomes; UP000002428; Chromosome A.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IEA:EnsemblFungi.
DR   GO; GO:0034247; P:snoRNA splicing; IEA:EnsemblFungi.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039971; CWC24-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12930; PTHR12930; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..226
FT                   /note="Pre-mRNA-splicing factor CWC24"
FT                   /id="PRO_0000055886"
FT   ZN_FING         107..135
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         165..203
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25559 MW;  5F97F2B4119D5D29 CRC64;
     MFKKRSAASK TRKRVKVETP VQKPAVQKPA VAVKPVLDKS HVAKLEEEIA SRPELDQKAV
     GEADATAVRL KRLKEQATKH DRLNSEPVAS SKKIQQAANL RNTILTDFQP DVCKDFKQTG
     YCGYGDSCKF LHSRDDFKAG WTLATDWKID EQKEETRKEA VPFKCVLCKE SYERPVKTNC
     GHYFCQKCFV NRIKIDKSCF ICGENTEGIA KMATDLVPMD NANKDK