ID   CWC24_CRYNJ             Reviewed;         329 AA.
AC   P0CQ64; Q55MN0; Q5KB05;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Pre-mRNA-splicing factor CWC24;
GN   Name=CWC24; OrderedLocusNames=CNI04230;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC24 family. {ECO:0000305}.
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DR   EMBL; AE017349; AAW45613.1; -; Genomic_DNA.
DR   RefSeq; XP_572920.1; XM_572920.1.
DR   AlphaFoldDB; P0CQ64; -.
DR   STRING; 5207.AAW45613; -.
DR   PaxDb; P0CQ64; -.
DR   EnsemblFungi; AAW45613; AAW45613; CNI04230.
DR   GeneID; 3259777; -.
DR   KEGG; cne:CNI04230; -.
DR   VEuPathDB; FungiDB:CNI04230; -.
DR   eggNOG; KOG1813; Eukaryota.
DR   HOGENOM; CLU_050460_1_1_1; -.
DR   InParanoid; P0CQ64; -.
DR   OMA; PEDCYIC; -.
DR   OrthoDB; 1420266at2759; -.
DR   Proteomes; UP000002149; Chromosome 9.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034247; P:snoRNA splicing; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR039971; CWC24-like.
DR   InterPro; IPR000571; Znf_CCCH.
DR   InterPro; IPR036855; Znf_CCCH_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR12930; PTHR12930; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00356; ZnF_C3H1; 1.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS50103; ZF_C3H1; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome; Zinc; Zinc-finger.
FT   CHAIN           1..329
FT                   /note="Pre-mRNA-splicing factor CWC24"
FT                   /id="PRO_0000055887"
FT   ZN_FING         177..205
FT                   /note="C3H1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00723"
FT   ZN_FING         237..275
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  36222 MW;  A8D915B0B0AA77FA CRC64;
     MSEAPAPVVT FKKGPSRRPA QSRQRRRSPS PLDPVAEASA SASGSNVVRP ERKSLANPLV
     QGTKRRRTNA NNEEEEDGVG GGLDEFDYAA EGGLTRKGDE LATRANDWDL EDVDGQGQRD
     KKVRLDEDGE IVTDDGLYRG ASAYLPTINK TRETLDKKMK SGPIKATSHV RTITLMDYQP
     DVCKDYKETG FCGYGDSCKF LHDRGDYLAG WQLDKLPEEG VREVEEEDEE EEVPFACLIC
     RQPFTQPVVT KCGHYFCMGC AAKRFQKSPK CYACGAPTQG IFNIADKVIA KIEARNKARR
     EAREERAEQT GGGGIEIGGG SDEEGSDEE