ID   CWC25_ASPFU             Reviewed;         447 AA.
AC   Q4X1D7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Pre-mRNA-splicing factor cwc25;
GN   Name=cwc25; ORFNames=AFUA_2G10330;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; AAHF01000001; EAL93328.1; -; Genomic_DNA.
DR   RefSeq; XP_755366.1; XM_750273.1.
DR   AlphaFoldDB; Q4X1D7; -.
DR   SMR; Q4X1D7; -.
DR   STRING; 746128.CADAFUBP00002554; -.
DR   PRIDE; Q4X1D7; -.
DR   EnsemblFungi; EAL93328; EAL93328; AFUA_2G10330.
DR   GeneID; 3513759; -.
DR   KEGG; afm:AFUA_2G10330; -.
DR   VEuPathDB; FungiDB:Afu2g10330; -.
DR   eggNOG; KOG3869; Eukaryota.
DR   HOGENOM; CLU_025093_0_0_1; -.
DR   InParanoid; Q4X1D7; -.
DR   OMA; SWHPHTM; -.
DR   OrthoDB; 1635950at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..447
FT                   /note="Pre-mRNA-splicing factor cwc25"
FT                   /id="PRO_0000079584"
FT   REGION          153..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          15..59
FT                   /evidence="ECO:0000255"
FT   COILED          363..403
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        153..206
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   447 AA;  54253 MW;  CAAFB7C802B61366 CRC64;
     MGGDLNLKKS WHPSLLRNQE RVWAEEKRAL EERKRIEQLR REREEERQIQ ELQRLQEASG
     KGRQLNRVDW MYQAPSSATG HYAEEMEGYL LGKRRIDGIL LKNDESKKLE KGTDVVGANA
     APPPVNNPRD TMAKVMADPL LEIKKREQAA YENMVKESVR RSQHIRDKDR DRDRERRRDR
     GDRDRSRDRD RSHRRSRHED EDAHRSHRHR SHRHRSRSPL SPDRSDRKRG DDRDYRDERD
     RRDDRRDEHR GHDRRDDRRS ERDRRADRGD EDRHSSRYKD RDDRYDHSTR RRSYADRSPS
     PRRGNHYYDR RRTEDRSDGY HRDSRNHDRP EFYRGNDRKV NKEPRDSNLR ERSSNTRDEV
     AGNKEKVLEE ERKKKLAEMM SNADELEQKR LQRIAEVTAM EEKEREADEK QRSERGRFVG
     QLHRQLQEDS LDDRIRRSRG GLERMED