CWC25_CANAL
ID CWC25_CANAL Reviewed; 221 AA.
AC Q59LQ5; A0A1D8PNV8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Pre-mRNA-splicing factor CWC25;
GN Name=CWC25; OrderedLocusNames=CAALFM_C504080CA;
GN ORFNames=CaO19.1281, CaO19.8868;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR EMBL; CP017627; AOW29817.1; -; Genomic_DNA.
DR RefSeq; XP_710662.2; XM_705570.2.
DR AlphaFoldDB; Q59LQ5; -.
DR SMR; Q59LQ5; -.
DR STRING; 237561.Q59LQ5; -.
DR GeneID; 3647731; -.
DR KEGG; cal:CAALFM_C504080CA; -.
DR CGD; CAL0000183063; orf19.8868.
DR VEuPathDB; FungiDB:C5_04080C_A; -.
DR eggNOG; KOG3869; Eukaryota.
DR HOGENOM; CLU_025093_3_0_1; -.
DR InParanoid; Q59LQ5; -.
DR OrthoDB; 1635950at2759; -.
DR PRO; PR:Q59LQ5; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR019339; CIR_N_dom.
DR InterPro; IPR022209; CWC25.
DR Pfam; PF10197; Cir_N; 1.
DR Pfam; PF12542; CWC25; 1.
DR SMART; SM01083; Cir_N; 1.
PE 3: Inferred from homology;
KW Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW Spliceosome.
FT CHAIN 1..221
FT /note="Pre-mRNA-splicing factor CWC25"
FT /id="PRO_0000079585"
FT REGION 145..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 14..56
FT /evidence="ECO:0000255"
FT COMPBIAS 145..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..190
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..221
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 221 AA; 25793 MW; EF6D19E38092195F CRC64;
MAGDLNLKKS WNPALVKNQQ KVWEEEQQKL DELKRIKERN QEYKQEQEYL ELLKLQHGDQ
FQIKDLNKQQ KLKISKLNWM YDDVPFEGNE KVEENSSGFI ESNVEFTDGK SKVENLLKGN
HVVGKKRDGS GTSDRINKII GVGMTKSSKV SYSDDPLLKI KQQQQQAQRV ARKQHPSDKH
SHRSRHSSKS SSDRVHKSHE HERSRKHNSS HTRHKDGSPH R
