ID   CWC25_CRYNJ             Reviewed;         434 AA.
AC   P0CM98; Q55TN7; Q5KIP8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Pre-mRNA-splicing factor CWC25;
GN   Name=CWC25; OrderedLocusNames=CND02200;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; AE017344; AAW42990.1; -; Genomic_DNA.
DR   RefSeq; XP_570297.1; XM_570297.1.
DR   AlphaFoldDB; P0CM98; -.
DR   SMR; P0CM98; -.
DR   STRING; 5207.AAW42990; -.
DR   PaxDb; P0CM98; -.
DR   EnsemblFungi; AAW42990; AAW42990; CND02200.
DR   GeneID; 3257215; -.
DR   KEGG; cne:CND02200; -.
DR   VEuPathDB; FungiDB:CND02200; -.
DR   eggNOG; KOG3869; Eukaryota.
DR   HOGENOM; CLU_025093_0_0_1; -.
DR   InParanoid; P0CM98; -.
DR   OMA; SWHPHTM; -.
DR   OrthoDB; 1272107at2759; -.
DR   Proteomes; UP000002149; Chromosome 4.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..434
FT                   /note="Pre-mRNA-splicing factor CWC25"
FT                   /id="PRO_0000079587"
FT   REGION          43..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          156..412
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          20..61
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        163..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..280
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        296..321
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..401
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   434 AA;  50153 MW;  D5534B3F7F9625BB CRC64;
     MGGGDLNMKK SWHPVLLVNQ ERVWKAEKVA NEEKKMLAQL RKEREEERQL EELHRLQEAS
     TGKKRVEKLD WMYAAPSTEG GALGGARIGE RDMEEYLLGK KRVDEVLGQG DKNIGAASRE
     FIALQNANTA RDTAAKIRED PLLAIKKQEQ AALAALMNRP DIRKQLRAAK KAKETKGREG
     ESKEERKARK RAEKEERRKS KHRYHDSRSP PSDYYDDRDH RRHRDSYDSQ DRENRRTYRD
     RSDRSRTRSE SPKREKKEKD YSNRDRDYRR RNDTTRGSFD ESPRKGGGNR WGSHGPDGYR
     RSDHRDDGFR ERQRGDRIPP PRHLSYNHST PDVRPSSPPS SSAAPVNRNT STLEDQRAAR
     LAAMSASADE LYSSRSKSLA ARAEEERREQ EKDEKMRQKY GKEQASANFF SQQSQLGLGE
     ALQRRGGKGL LKDI