ID   CWC25_DEBHA             Reviewed;         244 AA.
AC   Q6BNE1; B5RU56;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Pre-mRNA-splicing factor CWC25;
GN   Name=CWC25; OrderedLocusNames=DEHA2E22506g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAR65869.1; -; Genomic_DNA.
DR   RefSeq; XP_002770528.1; XM_002770482.1.
DR   AlphaFoldDB; Q6BNE1; -.
DR   SMR; Q6BNE1; -.
DR   STRING; 4959.XP_002770528.1; -.
DR   EnsemblFungi; CAR65869; CAR65869; DEHA2E22506g.
DR   GeneID; 8998824; -.
DR   KEGG; dha:DEHA2E22506g; -.
DR   VEuPathDB; FungiDB:DEHA2E22506g; -.
DR   eggNOG; KOG3869; Eukaryota.
DR   HOGENOM; CLU_025093_3_0_1; -.
DR   InParanoid; Q6BNE1; -.
DR   OMA; VEWMYAV; -.
DR   OrthoDB; 1635950at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..244
FT                   /note="Pre-mRNA-splicing factor CWC25"
FT                   /id="PRO_0000079588"
FT   REGION          124..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          27..57
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        124..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..165
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..211
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  28607 MW;  903C12295A7329EE CRC64;
     MPGDLNLKKS WHPGLMKNQK KLWEQEQEAL GEHLKIKAKS EELKKEKEKQ ELIKLQYGDA
     NNVPIKVKRE LNNLNWMYDD SKSGNKSNSE FNDMDDEFLL GKRKVENMLS GNKYIDTKET
     SRFEEAISSS NNGDKNIQND PLIRIKNEQL KKYQSVKDSG RHSSKDRHRS RDRSPNRHTF
     RHKSDNDKVS KHRHSSHRES RSGRSKSKSS HRHSRDKDSI DGSKDYSHLS QRDNTKTPSE
     FITY