ID   CWC25_KLULA             Reviewed;         206 AA.
AC   Q6CUQ5; Q707Z1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pre-mRNA-splicing factor CWC25;
GN   Name=CWC25; OrderedLocusNames=KLLA0C03069g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50.
RC   STRAIN=CBS 2549;
RX   PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA   Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT   "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01185.1; -; Genomic_DNA.
DR   EMBL; AJ617304; CAE84414.1; -; Genomic_DNA.
DR   RefSeq; XP_452334.1; XM_452334.1.
DR   AlphaFoldDB; Q6CUQ5; -.
DR   SMR; Q6CUQ5; -.
DR   STRING; 28985.XP_452334.1; -.
DR   EnsemblFungi; CAH01185; CAH01185; KLLA0_C03069g.
DR   GeneID; 2892264; -.
DR   KEGG; kla:KLLA0_C03069g; -.
DR   eggNOG; KOG3869; Eukaryota.
DR   HOGENOM; CLU_025093_3_1_1; -.
DR   InParanoid; Q6CUQ5; -.
DR   OMA; IEKERQF; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..206
FT                   /note="Pre-mRNA-splicing factor CWC25"
FT                   /id="PRO_0000079591"
FT   REGION          165..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          17..63
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        183..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   206 AA;  24207 MW;  1EE1007D15C9B57C CRC64;
     MSDLNLLKSW NPKLVKNRKK VWEAQQQLVE ENKKIKERQK EIEKERELDR YSSLIRDEDQ
     KNVKRKTGLE WMYDNTSTAL TENVDYLLGK KEITDTLLDL SGNNNKSEKS ENQKQTIRKH
     YQGIEDVICS KTNHKNVDLS SDDPMAKFKA AKQAHLKTLK QNIQPTSHEY PVHKPLRGAN
     SKRYDSGNGS RSNYKNSRYN NKYYRS