ID   CWC25_NEUCR             Reviewed;         444 AA.
AC   Q7SI59;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Pre-mRNA-splicing factor cwc25;
DE   AltName: Full=mRNA-splicing protein 6;
GN   Name=msp-6; Synonyms=cwc25; ORFNames=B22I21.170, NCU00592;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; BX842641; CAE76603.1; -; Genomic_DNA.
DR   EMBL; CM002236; EAA36496.1; -; Genomic_DNA.
DR   RefSeq; XP_965732.1; XM_960639.2.
DR   AlphaFoldDB; Q7SI59; -.
DR   SMR; Q7SI59; -.
DR   STRING; 5141.EFNCRP00000000947; -.
DR   PRIDE; Q7SI59; -.
DR   EnsemblFungi; EAA36496; EAA36496; NCU00592.
DR   GeneID; 3881874; -.
DR   KEGG; ncr:NCU00592; -.
DR   VEuPathDB; FungiDB:NCU00592; -.
DR   HOGENOM; CLU_025093_0_0_1; -.
DR   InParanoid; Q7SI59; -.
DR   Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..444
FT                   /note="Pre-mRNA-splicing factor cwc25"
FT                   /id="PRO_0000079592"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..65
FT                   /evidence="ECO:0000255"
FT   COILED          364..417
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        184..198
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..285
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..348
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..415
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  51402 MW;  7FF854C12008FA6C CRC64;
     MGSGDLNMKK SWHPQRSGNV AATQKAEAEA IAERKKLQQR LQEIEEERRK EEIQKALEAA
     GGKRKIDRVE WMYSGPTDGQ AGDSAETEAY LLGKRRIDKL LQDNDTKKAL SKQSQQDVLS
     AAGPAPVVTN ARDVATKIRE DPLLAIKRQE QQAYEAMMND PIKRRQLLAS MGIDDSQIAA
     KGGKEQRRHK HRSHHHRSDR HRDRDDDRDR DSARDRDRDR HSRRRRSDSR DRSRSRSPRR
     RSDSEEDRSK QRRRDSPDRT RRRDRDQSRS RGNRDRDDDR SRRHRFPQGR SRSRSGSPGG
     RSSRRREYSR ERDSGGPSSR RDDRNSRDQN RPRRDYAKED EQPKYDGGLN KGGRRQQQPD
     GDHKNAEEER AKKLAAMQAA ATDLDKAREE RLKALAEAER AEREADEKAR QQNKKFRGGD
     AGFMSGLHSR AADMKIADRM NGRV