ID   CWC25_USTMA             Reviewed;         428 AA.
AC   Q4P6I3; A0A0D1DYZ4;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Pre-mRNA-splicing factor CWC25;
GN   Name=CWC25; ORFNames=UMAG_10430;
OS   Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX   NCBI_TaxID=237631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=521 / FGSC 9021;
RX   PubMed=17080091; DOI=10.1038/nature05248;
RA   Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA   Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA   Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA   Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA   Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA   Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA   Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA   Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA   Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA   Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA   Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA   Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA   Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA   Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA   Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA   Birren B.W.;
RT   "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT   maydis.";
RL   Nature 444:97-101(2006).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=521 / FGSC 9021;
RA   Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; CM003151; KIS67785.1; -; Genomic_DNA.
DR   RefSeq; XP_011390781.1; XM_011392479.1.
DR   AlphaFoldDB; Q4P6I3; -.
DR   SMR; Q4P6I3; -.
DR   STRING; 5270.UM04280P0; -.
DR   PRIDE; Q4P6I3; -.
DR   EnsemblFungi; KIS67785; KIS67785; UMAG_10430.
DR   GeneID; 23566466; -.
DR   KEGG; uma:UMAG_10430; -.
DR   VEuPathDB; FungiDB:UMAG_10430; -.
DR   eggNOG; KOG3869; Eukaryota.
DR   InParanoid; Q4P6I3; -.
DR   OrthoDB; 1406866at2759; -.
DR   Proteomes; UP000000561; Chromosome 12.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..428
FT                   /note="Pre-mRNA-splicing factor CWC25"
FT                   /id="PRO_0000079594"
FT   REGION          40..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..380
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..65
FT                   /evidence="ECO:0000255"
FT   COILED          326..389
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        170..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..342
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  50662 MW;  DE71B4EEAE2731FD CRC64;
     MGGGDLNTKK SWHPLLQVNQ ERVWKREKEA LEERKKLEEL RREREQEREM QQLQRLQEEA
     GGKKRIDRVD WMYATPATTG SGSAAEMEDY LLGKKRVDKL LQGEENKEMS KTTQKSLVSL
     QNANSARDLA AKIREDPMLA IKQQEQAAYE ALLRDPTRLR QLKMQAGIDT DTQSKDERRR
     SKEEKRRRHD RDEHRRRGSR HGESRSESRS HSRRDDRDRK SSWNEGSSSR RHDGDEERRS
     LKRHRDDQDR DRHRYERRLH DADDSRPASR SNRDRRDKDA VDESSSRQST SYSRSRSRSP
     PARDYRNDKR LSSSSAFTRP SNGGSARNRE EDEERKQQAR QLKLQEMEQN ARSMEQQRSS
     YVSKINAEEA EQERREAELR QKLIDARSKG HGDGKGNFIM DQQRKTFHDS VDLAERMRRD
     RARLQRVD