ID   CWC25_YARLI             Reviewed;         561 AA.
AC   Q6C1V6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Pre-mRNA-splicing factor CWC25;
GN   Name=CWC25; OrderedLocusNames=YALI0F13057g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC25 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78163.1; -; Genomic_DNA.
DR   RefSeq; XP_505356.1; XM_505356.1.
DR   AlphaFoldDB; Q6C1V6; -.
DR   SMR; Q6C1V6; -.
DR   STRING; 4952.CAG78163; -.
DR   PRIDE; Q6C1V6; -.
DR   EnsemblFungi; CAG78163; CAG78163; YALI0_F13057g.
DR   GeneID; 2909011; -.
DR   KEGG; yli:YALI0F13057g; -.
DR   VEuPathDB; FungiDB:YALI0_F13057g; -.
DR   HOGENOM; CLU_485892_0_0_1; -.
DR   InParanoid; Q6C1V6; -.
DR   OMA; HESEDPC; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR019339; CIR_N_dom.
DR   InterPro; IPR022209; CWC25.
DR   Pfam; PF10197; Cir_N; 1.
DR   Pfam; PF12542; CWC25; 1.
DR   SMART; SM01083; Cir_N; 1.
PE   3: Inferred from homology;
KW   Coiled coil; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   Spliceosome.
FT   CHAIN           1..561
FT                   /note="Pre-mRNA-splicing factor CWC25"
FT                   /id="PRO_0000079595"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..65
FT                   /evidence="ECO:0000255"
FT   COILED          326..389
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        122..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        182..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..311
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..403
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..440
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        452..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        496..561
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   561 AA;  66044 MW;  61374B600C44CB6B CRC64;
     MPGDLNLKKS WHPGLHKNQA VVHAKEQEAL EERRRIQERQ KEIKQQRERD ELQKLQEMAT
     GKKRVQKVEW MYQDPTAVGS QQAFNEKKVD ANSTDDYLLG KRRIDSIVKQ KGDLEAFDDS
     LDRFQPKTDK SESAGIVHKV KDDPMVAVRQ KGRELGYTDE ANESERRSRR ERSRSRERER
     RRPRRKREDS RDRRNRRDME REGERRRRRR DGERTRRRER NRDPSPSVSD DDRGYRQSSR
     EERDRKSSRE EGGRSRSRDR YRNRSRERYR DRSREERSRD RSRERLRSRR DRDRDRDRDR
     DRDRDRDNVQ SSGRSSGRSS VRSSARSERS LRDRSRSRDP DRDRDYRSRS RERDSGGGQG
     SDLSDEVGNG RSVLDERSTD MNASDGNSSH GYRADNEFSP SRSPVTRSHR DKRNSYRPEY
     KDEDDKRFAQ RKDKEKEMNA LPKGLQQMRA KLLASKKTTT VSGTSQTPTS APSGSQRTPS
     AASGSSPTGK AATDAKLSDR LARLKAMQED AKALEEERDE RLASKTKHEE AERLRDALLR
     QKSAHLGRSE FAREEERKDL K