ID   CWC26_CANAL             Reviewed;         281 AA.
AC   Q5AL13; A0A1D8PFM5;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Pre-mRNA-splicing factor CWC26;
GN   Name=CWC26; OrderedLocusNames=CAALFM_C113380WA;
GN   ORFNames=CaO19.12429, CaO19.4964;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC26 family. {ECO:0000305}.
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DR   EMBL; CP017623; AOW26943.1; -; Genomic_DNA.
DR   RefSeq; XP_722174.2; XM_717081.2.
DR   AlphaFoldDB; Q5AL13; -.
DR   STRING; 237561.Q5AL13; -.
DR   PRIDE; Q5AL13; -.
DR   GeneID; 3636217; -.
DR   KEGG; cal:CAALFM_C113380WA; -.
DR   CGD; CAL0000192262; orf19.12429.
DR   VEuPathDB; FungiDB:C1_13380W_A; -.
DR   eggNOG; KOG2654; Eukaryota.
DR   HOGENOM; CLU_090706_0_0_1; -.
DR   InParanoid; Q5AL13; -.
DR   OrthoDB; 1558074at2759; -.
DR   PRO; PR:Q5AL13; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070274; C:RES complex; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR018609; Bud13.
DR   Pfam; PF09736; Bud13; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..281
FT                   /note="Pre-mRNA-splicing factor CWC26"
FT                   /id="PRO_0000079599"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          142..181
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        96..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  32455 MW;  DF7EC598F21D5C8B CRC64;
     MSKRADYLSK YLNNELSDKP KKKKHKKKSS TTPATSMNIV VETPKPLGVP SIDNNEEYNE
     LNQQTKDNEV DVDEFAPVKL KTTQKSNKGF KRIDNGDIIT TNNTTTTTPP PSSLSSSSSV
     IKPNKLQPNQ ETIYRDSSGR IINDIKQRQE DLQQQKLHEE QLKQFTEIKT SKQDQINQEQ
     EIFKVKNGHV DNQFEDPMTS FIKDTTTTTK KEFEDVSKSK FVYNKGINIP NRFNIPAGYF
     WDGIDRSNGF EQMYLRKQTE YNYDKIDSKI NETYEIDIGD D