ID   CWC26_CRYNJ             Reviewed;         331 AA.
AC   P0CN00; Q55XX5; Q5KM20;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Pre-mRNA-splicing factor CWC26;
GN   Name=CWC26; OrderedLocusNames=CNB03290;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC26 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE017342; AAW41599.1; -; Genomic_DNA.
DR   RefSeq; XP_568906.1; XM_568906.1.
DR   AlphaFoldDB; P0CN00; -.
DR   SMR; P0CN00; -.
DR   STRING; 5207.AAW41599; -.
DR   PaxDb; P0CN00; -.
DR   EnsemblFungi; AAW41599; AAW41599; CNB03290.
DR   VEuPathDB; FungiDB:CNB03290; -.
DR   eggNOG; KOG2654; Eukaryota.
DR   HOGENOM; CLU_024195_0_1_1; -.
DR   InParanoid; P0CN00; -.
DR   OMA; EKYMSGP; -.
DR   OrthoDB; 1558074at2759; -.
DR   Proteomes; UP000002149; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070274; C:RES complex; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR018609; Bud13.
DR   Pfam; PF09736; Bud13; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..331
FT                   /note="Pre-mRNA-splicing factor CWC26"
FT                   /id="PRO_0000079601"
FT   REGION          23..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          186..216
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        26..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   331 AA;  37942 MW;  1E134C35575C40AB CRC64;
     MSDLKAYLAA KYMSGPKADA ILARSSDPTL KKKRKKQQTN EDYIGGSVKA EASGGLMLRD
     EDEVWGRSKN EDEEDDAPVI GKDLATFKGS KSSWATVANK SALPLPQAEP TSPQDIKPDI
     KEEPDIDGPA ASAPVQMTKR RGGLRTAAQL KEDTERELAE QRSPSPAEGE ERPDPTETVH
     RDATGKIIDV KKRQEEERIR EEEERRKEAE RKEWTKGMVQ RRDREERRRL EKKMAEADVG
     RSKDDVRMNK EMKEEERWND PAAAFLTKKK KKGPRRPKYE GPWAPNRFGI APGFRWDGVD
     RSNGFEKKYF QAQNTRARRE YEHNQWSVED M