ID   CWC26_KLULA             Reviewed;         268 AA.
AC   Q6CJ08;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Pre-mRNA-splicing factor CWC26;
GN   Name=CWC26; OrderedLocusNames=KLLA0F22407g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC26 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98789.1; -; Genomic_DNA.
DR   RefSeq; XP_456081.1; XM_456081.1.
DR   AlphaFoldDB; Q6CJ08; -.
DR   SMR; Q6CJ08; -.
DR   STRING; 28985.XP_456081.1; -.
DR   EnsemblFungi; CAG98789; CAG98789; KLLA0_F22407g.
DR   GeneID; 2895391; -.
DR   KEGG; kla:KLLA0_F22407g; -.
DR   eggNOG; KOG2654; Eukaryota.
DR   HOGENOM; CLU_086127_0_0_1; -.
DR   InParanoid; Q6CJ08; -.
DR   OMA; GYAPPNR; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070274; C:RES complex; IEA:EnsemblFungi.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0051237; P:maintenance of RNA location; IEA:EnsemblFungi.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR   InterPro; IPR018609; Bud13.
DR   Pfam; PF09736; Bud13; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..268
FT                   /note="Pre-mRNA-splicing factor CWC26"
FT                   /id="PRO_0000079604"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          104..170
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        27..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30745 MW;  14B1B13F50470E23 CRC64;
     MSLNDFLAKS YGSKHGKEKT KKSKDKSSHR KSDESKRVTS RNIDIIDKAN LITEENKKAA
     SSNKTGKSLW KNLETEKLEL VQHVDVDKKD DSKERMSSGA FAGLQTAEEM EKQIAEKEKL
     SMQKSGLLKK NQNTVYRDEK GKVIDGYEEE LKLREKANLT AKVRKEEELK IRNIGEVQIS
     KLDRKTEKSA LLSTEDPLNQ GNTLRGTNTS LLGRRLYEKN FPENRFGIVP GYRWDGVDRS
     NGFETKWFAK SHDIADQKIK EQTTNREF