ID   CWC26_NEUCR             Reviewed;         377 AA.
AC   Q7RWR8;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Pre-mRNA-splicing factor cwc-26;
GN   Name=cwc-26; ORFNames=29E8.540, NCU04362;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CWC26 family. {ECO:0000305}.
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DR   EMBL; CM002239; EAA26899.1; -; Genomic_DNA.
DR   EMBL; BX908809; CAF06087.1; -; Genomic_DNA.
DR   RefSeq; XP_956135.1; XM_951042.2.
DR   AlphaFoldDB; Q7RWR8; -.
DR   SMR; Q7RWR8; -.
DR   STRING; 5141.EFNCRP00000005232; -.
DR   EnsemblFungi; EAA26899; EAA26899; NCU04362.
DR   GeneID; 3872289; -.
DR   KEGG; ncr:NCU04362; -.
DR   VEuPathDB; FungiDB:NCU04362; -.
DR   HOGENOM; CLU_024195_0_0_1; -.
DR   InParanoid; Q7RWR8; -.
DR   OMA; EKYMSGP; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070274; C:RES complex; IBA:GO_Central.
DR   GO; GO:0005684; C:U2-type spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR018609; Bud13.
DR   Pfam; PF09736; Bud13; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; Nucleus;
KW   Reference proteome; Spliceosome.
FT   CHAIN           1..377
FT                   /note="Pre-mRNA-splicing factor cwc-26"
FT                   /id="PRO_0000079606"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          293..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          185..276
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   377 AA;  41636 MW;  8507646E19D037DE CRC64;
     MPSDKAAYLA AHYLSTDPPN KSSSSTSKKR KRKNKSAEDG LIIADDDDTS WAQAAKRDSD
     DDDFDGPVLA AGVVSADFRK AKKSGWKTVG SSSAFAKQAT TSTTTNSTKE DIDAAAAADA
     ILAQTAAETA ALAREAGGDD EVLVVDTTTG ATALTRSHQP AETATQAPIM SNGTHAGLQS
     ASAITAQLKA RQEAERLELE RIRAERDQQH PEDQEELVLR DATGRRIDAS MRRAEARRQQ
     AEAERKEAEK KRALKGEVQL EQARRRREEL EEAKLMPLAR SKDDEQLNAE LKQQDRWNDP
     MAQFLAPEEV KVKGRKKGTA GRRPTYKGPA PPNRYGIKPG YRWDGVDRSN GFEAERFKAL
     NRRERNKGLE YAWQMDE