ID   CWSA_MYCBO              Reviewed;         145 AA.
AC   P59977; A0A1R3XV73; X2BDR6;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Cell wall synthesis protein CwsA {ECO:0000255|HAMAP-Rule:MF_00927};
DE   AltName: Full=Cell wall synthesis and cell shape protein A {ECO:0000255|HAMAP-Rule:MF_00927};
GN   Name=cwsA {ECO:0000255|HAMAP-Rule:MF_00927};
GN   OrderedLocusNames=BQ2027_MB0008C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Required for regulated cell division, cell wall synthesis and
CC       the maintenance of cell shape. {ECO:0000255|HAMAP-Rule:MF_00927}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00927};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00927}.
CC       Note=Localizes to poles and midcell sites. {ECO:0000255|HAMAP-
CC       Rule:MF_00927}.
CC   -!- SIMILARITY: Belongs to the CwsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00927}.
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DR   EMBL; LT708304; SIT98350.1; -; Genomic_DNA.
DR   RefSeq; NP_853678.1; NC_002945.3.
DR   RefSeq; WP_003400307.1; NC_002945.4.
DR   AlphaFoldDB; P59977; -.
DR   BMRB; P59977; -.
DR   EnsemblBacteria; SIT98350; SIT98350; BQ2027_MB0008C.
DR   GeneID; 45423967; -.
DR   PATRIC; fig|233413.5.peg.11; -.
DR   OMA; KRPWVIA; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0042546; P:cell wall biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00927; CwsA; 1.
DR   InterPro; IPR024245; CwsA.
DR   Pfam; PF10814; CwsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Cell shape; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Cell wall synthesis protein CwsA"
FT                   /id="PRO_0000103639"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00927"
SQ   SEQUENCE   145 AA;  15681 MW;  7EC7CCD1189707D7 CRC64;
     MSEQVETRLT PRERLTRGLA YSAVGPVDVT RGLLELGVGL GLQSARSTAA GLRRRYREGR
     LAREVAAAQE TLAQELTAAQ DVVANLPQAL QDARTQRRSK HHLWIFAGIA AAILAGGAVA
     FSIVRRSSRP EPSPRPPSVE VQPRP