ID   CWSA_MYCTO              Reviewed;         145 AA.
AC   P9WJF2; L0T2A0; P71577;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Cell wall synthesis protein CwsA {ECO:0000255|HAMAP-Rule:MF_00927};
DE   AltName: Full=Cell wall synthesis and cell shape protein A {ECO:0000255|HAMAP-Rule:MF_00927};
GN   Name=cwsA {ECO:0000255|HAMAP-Rule:MF_00927}; OrderedLocusNames=MT0010;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for regulated cell division, cell wall synthesis and
CC       the maintenance of cell shape. {ECO:0000255|HAMAP-Rule:MF_00927}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00927};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00927}.
CC       Note=Localizes to poles and midcell sites. {ECO:0000255|HAMAP-
CC       Rule:MF_00927}.
CC   -!- SIMILARITY: Belongs to the CwsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00927}.
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DR   EMBL; AE000516; AAK44232.1; -; Genomic_DNA.
DR   PIR; F70698; F70698.
DR   RefSeq; WP_003400307.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJF2; -.
DR   BMRB; P9WJF2; -.
DR   EnsemblBacteria; AAK44232; AAK44232; MT0010.
DR   GeneID; 45423967; -.
DR   KEGG; mtc:MT0010; -.
DR   PATRIC; fig|83331.31.peg.11; -.
DR   HOGENOM; CLU_1914740_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0042546; P:cell wall biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00927; CwsA; 1.
DR   InterPro; IPR024245; CwsA.
DR   Pfam; PF10814; CwsA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Cell shape; Membrane;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Cell wall synthesis protein CwsA"
FT                   /id="PRO_0000427840"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00927"
SQ   SEQUENCE   145 AA;  15681 MW;  7EC7CCD1189707D7 CRC64;
     MSEQVETRLT PRERLTRGLA YSAVGPVDVT RGLLELGVGL GLQSARSTAA GLRRRYREGR
     LAREVAAAQE TLAQELTAAQ DVVANLPQAL QDARTQRRSK HHLWIFAGIA AAILAGGAVA
     FSIVRRSSRP EPSPRPPSVE VQPRP