CX001_HUMAN
ID CX001_HUMAN Reviewed; 111 AA.
AC O96002; Q14CW0;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Putative transmembrane protein CXorf1 {ECO:0000305};
GN Name=CXorf1 {ECO:0000303|PubMed:9881668};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=9881668; DOI=10.1089/dna.1998.17.1009;
RA Redolfi E., Montagna C., Mumm S., Affer M., Susani L., Reinbold R., Hol F.,
RA Vezzoni P., Cimino M., Zucchi I.;
RT "Identification of CXorf1, a novel intronless gene in Xq27.3 expressed in
RT human hippocampus.";
RL DNA Cell Biol. 17:1009-1016(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Brain. In the hippocampus it is mainly localized in
CC the granular-cell layer of the dentate gyrus and in the CA2-CA3
CC subfields of Ammon's horn. {ECO:0000269|PubMed:9881668}.
CC -!- CAUTION: Product of a dubious CDS prediction. Most probably an
CC erroneously predicted open reading frame in the 3' UTR of the SLITRK2
CC gene. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Y10607; CAA71614.1; -; Genomic_DNA.
DR EMBL; Y08902; CAA70110.1; -; mRNA.
DR EMBL; AL109653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC113600; AAI13601.1; -; mRNA.
DR EMBL; BC113604; AAI13605.1; -; mRNA.
DR RefSeq; NP_004700.1; NM_004709.2.
DR AlphaFoldDB; O96002; -.
DR BioGRID; 114589; 53.
DR iPTMnet; O96002; -.
DR PhosphoSitePlus; O96002; -.
DR BioMuta; CXorf1; -.
DR PaxDb; O96002; -.
DR PRIDE; O96002; -.
DR DNASU; 9142; -.
DR UCSC; uc004fch.4; human.
DR MIM; 300565; gene.
DR neXtProt; NX_O96002; -.
DR eggNOG; ENOG502TGP1; Eukaryota.
DR HOGENOM; CLU_2157570_0_0_1; -.
DR InParanoid; O96002; -.
DR PhylomeDB; O96002; -.
DR BioGRID-ORCS; 9142; 36 hits in 649 CRISPR screens.
DR Pharos; O96002; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; O96002; protein.
DR Genevisible; O96002; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 5: Uncertain;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..111
FT /note="Putative transmembrane protein CXorf1"
FT /id="PRO_0000079729"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 36
FT /note="S -> A (in dbSNP:rs3752359)"
FT /id="VAR_033766"
SQ SEQUENCE 111 AA; 13452 MW; 5EFA883C1329A522 CRC64;
MYSRLFYLKS SYIIYFEPLF SNAIINILSF INSLASPLTI FCFALSAQAL STIFYFRIFI
FIFHSWILLF HFYFTCSFKT YEHQHSKMVP AYRMQSPRAL PRTYLYVWPY K
