CX038_HUMAN
ID CX038_HUMAN Reviewed; 319 AA.
AC Q8TB03; B3KW28; D3DWB5; Q5JPF5; Q8N941;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Uncharacterized protein CXorf38;
GN Name=CXorf38;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-314, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8TB03; Q6ZTQ4: CDHR3; NbExp=3; IntAct=EBI-12024320, EBI-12143631;
CC Q8TB03; G5E9A7: DMWD; NbExp=3; IntAct=EBI-12024320, EBI-10976677;
CC Q8TB03; P22607: FGFR3; NbExp=3; IntAct=EBI-12024320, EBI-348399;
CC Q8TB03; P28799: GRN; NbExp=3; IntAct=EBI-12024320, EBI-747754;
CC Q8TB03; P42858: HTT; NbExp=15; IntAct=EBI-12024320, EBI-466029;
CC Q8TB03; O60333-2: KIF1B; NbExp=3; IntAct=EBI-12024320, EBI-10975473;
CC Q8TB03; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12024320, EBI-16439278;
CC Q8TB03; Q13952-2: NFYC; NbExp=3; IntAct=EBI-12024320, EBI-11956831;
CC Q8TB03; Q02548: PAX5; NbExp=3; IntAct=EBI-12024320, EBI-296331;
CC Q8TB03; P26367: PAX6; NbExp=3; IntAct=EBI-12024320, EBI-747278;
CC Q8TB03; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-12024320, EBI-396669;
CC Q8TB03; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-12024320, EBI-5235340;
CC Q8TB03; Q86WV8: TSC1; NbExp=3; IntAct=EBI-12024320, EBI-12806590;
CC Q8TB03; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-12024320, EBI-741480;
CC Q8TB03; O76024: WFS1; NbExp=3; IntAct=EBI-12024320, EBI-720609;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8TB03-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TB03-2; Sequence=VSP_014620;
CC Name=3;
CC IsoId=Q8TB03-3; Sequence=VSP_014621, VSP_014622;
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DR EMBL; AK095710; BAC04615.1; -; mRNA.
DR EMBL; AK123989; BAG53990.1; -; mRNA.
DR EMBL; AL832829; CAI46149.1; -; mRNA.
DR EMBL; CH471141; EAW59422.1; -; Genomic_DNA.
DR EMBL; CH471141; EAW59423.1; -; Genomic_DNA.
DR EMBL; BC025334; AAH25334.1; -; mRNA.
DR CCDS; CCDS14253.1; -. [Q8TB03-1]
DR CCDS; CCDS83467.1; -. [Q8TB03-2]
DR RefSeq; NP_001317384.1; NM_001330455.1. [Q8TB03-2]
DR RefSeq; NP_659407.1; NM_144970.2. [Q8TB03-1]
DR RefSeq; XP_005272646.2; XM_005272589.2. [Q8TB03-1]
DR RefSeq; XP_016884793.1; XM_017029304.1. [Q8TB03-2]
DR AlphaFoldDB; Q8TB03; -.
DR BioGRID; 127729; 7.
DR IntAct; Q8TB03; 16.
DR STRING; 9606.ENSP00000330488; -.
DR GlyGen; Q8TB03; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8TB03; -.
DR PhosphoSitePlus; Q8TB03; -.
DR BioMuta; CXorf38; -.
DR DMDM; 71153249; -.
DR EPD; Q8TB03; -.
DR jPOST; Q8TB03; -.
DR MassIVE; Q8TB03; -.
DR MaxQB; Q8TB03; -.
DR PaxDb; Q8TB03; -.
DR PeptideAtlas; Q8TB03; -.
DR PRIDE; Q8TB03; -.
DR ProteomicsDB; 73942; -. [Q8TB03-1]
DR ProteomicsDB; 73943; -. [Q8TB03-2]
DR ProteomicsDB; 73944; -. [Q8TB03-3]
DR Antibodypedia; 55857; 7 antibodies from 6 providers.
DR DNASU; 159013; -.
DR Ensembl; ENST00000327877.10; ENSP00000330488.5; ENSG00000185753.13. [Q8TB03-1]
DR Ensembl; ENST00000378421.1; ENSP00000367677.1; ENSG00000185753.13. [Q8TB03-2]
DR Ensembl; ENST00000378426.5; ENSP00000367683.1; ENSG00000185753.13. [Q8TB03-2]
DR GeneID; 159013; -.
DR KEGG; hsa:159013; -.
DR MANE-Select; ENST00000327877.10; ENSP00000330488.5; NM_144970.3; NP_659407.1.
DR UCSC; uc004dev.2; human. [Q8TB03-1]
DR CTD; 159013; -.
DR GeneCards; CXorf38; -.
DR HGNC; HGNC:28589; CXorf38.
DR HPA; ENSG00000185753; Low tissue specificity.
DR neXtProt; NX_Q8TB03; -.
DR OpenTargets; ENSG00000185753; -.
DR PharmGKB; PA134955144; -.
DR VEuPathDB; HostDB:ENSG00000185753; -.
DR eggNOG; ENOG502QR6P; Eukaryota.
DR GeneTree; ENSGT00390000006290; -.
DR HOGENOM; CLU_064748_0_0_1; -.
DR InParanoid; Q8TB03; -.
DR OMA; DGCEYET; -.
DR OrthoDB; 1360283at2759; -.
DR PhylomeDB; Q8TB03; -.
DR TreeFam; TF333077; -.
DR PathwayCommons; Q8TB03; -.
DR SignaLink; Q8TB03; -.
DR BioGRID-ORCS; 159013; 16 hits in 696 CRISPR screens.
DR ChiTaRS; CXorf38; human.
DR GenomeRNAi; 159013; -.
DR Pharos; Q8TB03; Tdark.
DR PRO; PR:Q8TB03; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q8TB03; protein.
DR Bgee; ENSG00000185753; Expressed in monocyte and 180 other tissues.
DR Genevisible; Q8TB03; HS.
DR InterPro; IPR027897; DUF4559.
DR PANTHER; PTHR35083; PTHR35083; 1.
DR Pfam; PF15112; DUF4559; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..319
FT /note="Uncharacterized protein CXorf38"
FT /id="PRO_0000079732"
FT MOD_RES 61
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q8C5K5"
FT MOD_RES 314
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..119
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_014620"
FT VAR_SEQ 118..155
FT /note="AFMPRGLADKQGPEECDAVALLSLINSCDHFVVDRKKV -> GLDLLSRLEC
FT SGESELIATLNSWAQAILLPQPLEYLGL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014621"
FT VAR_SEQ 156..319
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014622"
FT VARIANT 176
FT /note="T -> A (in dbSNP:rs17145855)"
FT /id="VAR_050936"
SQ SEQUENCE 319 AA; 36670 MW; 6614EFF8D47953D9 CRC64;
MVLSELAARL NCAEYKNWVK AGHCLLLLRS CLQGFVGREV LSFHRGLLAA APGLGPRAVC
RGGSRCSPRA RQFQPQCQVC AEWKREILRH HVNRNGDVHW GNCRPGRWPV DAWEVAKAFM
PRGLADKQGP EECDAVALLS LINSCDHFVV DRKKVTEVIK CRNEIMHSSE MKVSSTWLRD
FQMKIQNFLN EFKNIPEIVA VYSRIEQLLT SDWAVHIPEE DQRDGCECEM GTYLSESQVN
EIEMQLLKEK LQEIYLQAEE QEVLPEELSN RLEVVKEFLR NNEDLRNGLT EDMQKLDSLC
LHQKLDSQEP GRQTPDRKA
