CX049_HUMAN
ID CX049_HUMAN Reviewed; 514 AA.
AC A8MYA2;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-NOV-2014, sequence version 3.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Uncharacterized protein CXorf49 {ECO:0000305};
GN Name=CXorf49 {ECO:0000312|HGNC:HGNC:30891};
GN and
GN Name=CXorf49B {ECO:0000312|HGNC:HGNC:34229};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-188.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; BX276092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BI827666; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS75991.1; -.
DR CCDS; CCDS75992.1; -.
DR RefSeq; NP_001138611.1; NM_001145139.1.
DR RefSeq; NP_001138612.1; NM_001145140.1.
DR AlphaFoldDB; A8MYA2; -.
DR SMR; A8MYA2; -.
DR STRING; 9606.ENSP00000480355; -.
DR iPTMnet; A8MYA2; -.
DR PhosphoSitePlus; A8MYA2; -.
DR BioMuta; CXorf49; -.
DR MassIVE; A8MYA2; -.
DR PeptideAtlas; A8MYA2; -.
DR PRIDE; A8MYA2; -.
DR ProteomicsDB; 2386; -.
DR DNASU; 100130361; -.
DR Ensembl; ENST00000535490.3; ENSP00000480355.1; ENSG00000215115.7.
DR Ensembl; ENST00000542739.3; ENSP00000482270.1; ENSG00000215113.7.
DR GeneID; 100130361; -.
DR GeneID; 100132994; -.
DR KEGG; hsa:100130361; -.
DR KEGG; hsa:100132994; -.
DR MANE-Select; ENST00000535490.3; ENSP00000480355.1; NM_001145140.2; NP_001138612.1.
DR MANE-Select; ENST00000542739.3; ENSP00000482270.1; NM_001145139.2; NP_001138611.1.
DR UCSC; uc011mpy.3; human.
DR CTD; 100130361; -.
DR CTD; 100132994; -.
DR GeneCards; CXorf49; -.
DR GeneCards; CXorf49B; -.
DR HGNC; HGNC:30891; CXorf49.
DR HGNC; HGNC:34229; CXorf49B.
DR HPA; ENSG00000215113; Tissue enriched (testis).
DR HPA; ENSG00000215115; Tissue enriched (testis).
DR neXtProt; NX_A8MYA2; -.
DR OpenTargets; ENSG00000215115; -.
DR VEuPathDB; HostDB:ENSG00000215113; -.
DR VEuPathDB; HostDB:ENSG00000215115; -.
DR eggNOG; KOG3544; Eukaryota.
DR GeneTree; ENSGT00390000015252; -.
DR HOGENOM; CLU_037026_1_0_1; -.
DR InParanoid; A8MYA2; -.
DR OMA; NRHEVPK; -.
DR OrthoDB; 756568at2759; -.
DR PathwayCommons; A8MYA2; -.
DR SignaLink; A8MYA2; -.
DR BioGRID-ORCS; 100130361; 7 hits in 146 CRISPR screens.
DR BioGRID-ORCS; 100132994; 8 hits in 138 CRISPR screens.
DR Pharos; A8MYA2; Tdark.
DR PRO; PR:A8MYA2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; A8MYA2; protein.
DR Bgee; ENSG00000215113; Expressed in right testis and 35 other tissues.
DR InterPro; IPR027822; DUF4641.
DR PANTHER; PTHR31866; PTHR31866; 1.
DR Pfam; PF15483; DUF4641; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..514
FT /note="Uncharacterized protein CXorf49"
FT /id="PRO_0000343895"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 54417 MW; 20C31FDC3E87C618 CRC64;
MSSPDKVSVC GAGFDLEGGK KAGSRTASPG APGAHSHGLD LGVPGSGDGK SESGFTDPEG
FSFESESELI EQGRVVLWGR EGRPGTPVDD QGDVVDYSFY LADEPAAIVP PPSVQGHPFP
EGAAAEGSAE NWADAEVGPS GRDVLGHSPG KWQQASAGRL HLCGPGPVRA WKNPERGSKS
RWSLRVDPQQ PSAKGPTRLP THDSDSADES SDLPLMKVGI CRNEGSQAKP GSPKKRADTS
RQASFHCKES YLPVPGRFLT SAPRGLTPVA ERPAVGELED SPQKKMQSRA WGKVEVRPSC
SGAAAAGALP QGLSRRKMAG GKKSLGGASQ LALGRGFPAC GERLSAAPPE PATFPPFSGV
RPQGMSKKPQ KPKHSSPGKK PAGRKTRESQ AAAREDNDPN RDEVPRAQLP THRPGLPRLS
VRRGEFSSSD PNIRAPQLPG TSEPSAYSPG GLVPRRHAPS GNQQPPVHPP RPERQQQPPG
AQGCPRCIWL QREIEDLTQQ LAAMQFLTDK FQDL
