CX058_HUMAN
ID CX058_HUMAN Reviewed; 332 AA.
AC Q96LI9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Uncharacterized protein CXorf58 {ECO:0000305};
GN Name=CXorf58 {ECO:0000312|HGNC:HGNC:26356};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-24.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-24.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
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DR EMBL; AK058173; BAB71702.1; -; mRNA.
DR EMBL; AC079376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117344; AAI17345.1; -; mRNA.
DR EMBL; BC117346; AAI17347.1; -; mRNA.
DR CCDS; CCDS14209.1; -.
DR RefSeq; NP_001163045.1; NM_001169574.1.
DR RefSeq; NP_689974.2; NM_152761.2.
DR RefSeq; XP_011543775.1; XM_011545473.2.
DR AlphaFoldDB; Q96LI9; -.
DR BioGRID; 129018; 6.
DR IntAct; Q96LI9; 2.
DR STRING; 9606.ENSP00000368511; -.
DR iPTMnet; Q96LI9; -.
DR PhosphoSitePlus; Q96LI9; -.
DR BioMuta; CXorf58; -.
DR DMDM; 134047748; -.
DR EPD; Q96LI9; -.
DR MassIVE; Q96LI9; -.
DR PaxDb; Q96LI9; -.
DR PeptideAtlas; Q96LI9; -.
DR PRIDE; Q96LI9; -.
DR ProteomicsDB; 77213; -.
DR Antibodypedia; 24554; 47 antibodies from 12 providers.
DR DNASU; 254158; -.
DR Ensembl; ENST00000379211.8; ENSP00000368511.3; ENSG00000165182.12.
DR GeneID; 254158; -.
DR KEGG; hsa:254158; -.
DR MANE-Select; ENST00000379211.8; ENSP00000368511.3; NM_152761.3; NP_689974.2.
DR UCSC; uc004daz.2; human.
DR CTD; 254158; -.
DR GeneCards; CXorf58; -.
DR HGNC; HGNC:26356; CXorf58.
DR HPA; ENSG00000165182; Tissue enriched (testis).
DR neXtProt; NX_Q96LI9; -.
DR OpenTargets; ENSG00000165182; -.
DR PharmGKB; PA145149060; -.
DR VEuPathDB; HostDB:ENSG00000165182; -.
DR eggNOG; ENOG502QUVK; Eukaryota.
DR GeneTree; ENSGT00510000048637; -.
DR HOGENOM; CLU_065443_1_0_1; -.
DR InParanoid; Q96LI9; -.
DR OrthoDB; 1231039at2759; -.
DR PhylomeDB; Q96LI9; -.
DR TreeFam; TF328500; -.
DR PathwayCommons; Q96LI9; -.
DR SignaLink; Q96LI9; -.
DR BioGRID-ORCS; 254158; 14 hits in 688 CRISPR screens.
DR ChiTaRS; CXorf58; human.
DR GenomeRNAi; 254158; -.
DR Pharos; Q96LI9; Tdark.
DR PRO; PR:Q96LI9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q96LI9; protein.
DR Bgee; ENSG00000165182; Expressed in sperm and 67 other tissues.
DR ExpressionAtlas; Q96LI9; baseline and differential.
DR Genevisible; Q96LI9; HS.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..332
FT /note="Uncharacterized protein CXorf58"
FT /id="PRO_0000271066"
FT REGION 306..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 24
FT /note="R -> C (in dbSNP:rs2707164)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_029857"
FT VARIANT 187
FT /note="R -> H (in dbSNP:rs16982852)"
FT /id="VAR_029858"
SQ SEQUENCE 332 AA; 38899 MW; 826A5D510D56F543 CRC64;
MNRSSNVPRK GILKSGTRSL QKVRRVHFAN ARNARSLLSM LKDISAQIIQ RAWLSHTNKM
IFRLLKHAIC AAEFYVTHEI LKKVAPLEAK LIKDPTMQCK IRFRFRGETF PPFIVFKIFL
HTDGHGYKYF SGKNVLMPSS KAVDDACKLM GERKFHRIIM EDERIFPKSK VTDIMDVVTM
QDYVQYRSFF DEAPAFSGGR NNSWRKLNLE NIPRTMLMYD IVHYSESGVI SNRLRNEMKF
LLQRPVTQEI HKHQLRIVSE IRGPYLTVQP LYRPYKQQNQ VKFLGRRSKQ AQMKVEKMRK
VYLAKEKNTS EVTEPKTGPS GTKDNYHLHS IF
