ID   CX064_CONPO             Reviewed;          71 AA.
AC   P0DUQ8;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   23-FEB-2022, entry version 2.
DE   RecName: Full=Conotoxin Pl064 {ECO:0000303|PubMed:26506909};
DE   Flags: Precursor;
OS   Conus planorbis (Planorbis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Strategoconus.
OX   NCBI_TaxID=97183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-69, AND SUBCELLULAR
RP   LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=26506909; DOI=10.1002/pmic.201500220;
RA   Jin A.H., Vetter I., Himaya S.W., Alewood P.F., Lewis R.J., Dutertre S.;
RT   "Transcriptome and proteome of Conus planorbis identify the nicotinic
RT   receptors as primary target for the defensive venom.";
RL   Proteomics 15:4030-4040(2015).
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26506909}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:26506909}.
CC   -!- MISCELLANEOUS: The mature peptide does not contain cysteine residue.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin NSf-1 superfamily. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..28
FT                   /evidence="ECO:0000305|PubMed:26506909"
FT                   /id="PRO_0000453217"
FT   CHAIN           29..69
FT                   /note="Conotoxin Pl064"
FT                   /evidence="ECO:0000269|PubMed:26506909"
FT                   /id="PRO_0000453218"
SQ   SEQUENCE   71 AA;  8155 MW;  3B9FF3BE5F4C10F5 CRC64;
     MSRLFMILLV ICVITLGTDA SQAEDSGTEK KSWPMPDADL KAFQSWPLTD PDLKSAFKQY
     NWQRMPYGTR K