CX066_HUMAN
ID CX066_HUMAN Reviewed; 361 AA.
AC Q5JRM2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Uncharacterized protein CXorf66;
DE Flags: Precursor;
GN Name=CXorf66;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JRM2; Q13520: AQP6; NbExp=3; IntAct=EBI-12823659, EBI-13059134;
CC Q5JRM2; Q12797-6: ASPH; NbExp=3; IntAct=EBI-12823659, EBI-12092171;
CC Q5JRM2; P50402: EMD; NbExp=3; IntAct=EBI-12823659, EBI-489887;
CC Q5JRM2; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-12823659, EBI-781551;
CC Q5JRM2; O43561-2: LAT; NbExp=3; IntAct=EBI-12823659, EBI-8070286;
CC Q5JRM2; Q8WZA1: POMGNT1; NbExp=3; IntAct=EBI-12823659, EBI-3912424;
CC Q5JRM2; Q9NS64: RPRM; NbExp=3; IntAct=EBI-12823659, EBI-1052363;
CC Q5JRM2; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-12823659, EBI-10244780;
CC Q5JRM2; O60499-2: STX10; NbExp=3; IntAct=EBI-12823659, EBI-12094584;
CC Q5JRM2; Q9Y320: TMX2; NbExp=3; IntAct=EBI-12823659, EBI-6447886;
CC Q5JRM2; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-12823659, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AL590077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137148; AAI37149.1; -; mRNA.
DR EMBL; BC137149; AAI37150.1; -; mRNA.
DR CCDS; CCDS35411.1; -.
DR RefSeq; NP_001013421.1; NM_001013403.2.
DR AlphaFoldDB; Q5JRM2; -.
DR BioGRID; 131442; 35.
DR IntAct; Q5JRM2; 11.
DR STRING; 9606.ENSP00000359571; -.
DR GlyGen; Q5JRM2; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q5JRM2; -.
DR PhosphoSitePlus; Q5JRM2; -.
DR BioMuta; CXorf66; -.
DR DMDM; 74741872; -.
DR MassIVE; Q5JRM2; -.
DR PaxDb; Q5JRM2; -.
DR PeptideAtlas; Q5JRM2; -.
DR PRIDE; Q5JRM2; -.
DR ProteomicsDB; 63099; -.
DR Antibodypedia; 44987; 45 antibodies from 12 providers.
DR DNASU; 347487; -.
DR Ensembl; ENST00000370540.2; ENSP00000359571.1; ENSG00000203933.3.
DR GeneID; 347487; -.
DR KEGG; hsa:347487; -.
DR MANE-Select; ENST00000370540.2; ENSP00000359571.1; NM_001013403.3; NP_001013421.1.
DR UCSC; uc004fbb.4; human.
DR CTD; 347487; -.
DR DisGeNET; 347487; -.
DR GeneCards; CXorf66; -.
DR HGNC; HGNC:33743; CXorf66.
DR HPA; ENSG00000203933; Tissue enriched (testis).
DR neXtProt; NX_Q5JRM2; -.
DR OpenTargets; ENSG00000203933; -.
DR PharmGKB; PA164718516; -.
DR VEuPathDB; HostDB:ENSG00000203933; -.
DR eggNOG; ENOG502T3E1; Eukaryota.
DR GeneTree; ENSGT00390000004226; -.
DR HOGENOM; CLU_061820_0_0_1; -.
DR InParanoid; Q5JRM2; -.
DR OMA; HPQNEIS; -.
DR OrthoDB; 1014351at2759; -.
DR PhylomeDB; Q5JRM2; -.
DR TreeFam; TF352168; -.
DR PathwayCommons; Q5JRM2; -.
DR BioGRID-ORCS; 347487; 8 hits in 683 CRISPR screens.
DR GenomeRNAi; 347487; -.
DR Pharos; Q5JRM2; Tdark.
DR PRO; PR:Q5JRM2; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JRM2; protein.
DR Bgee; ENSG00000203933; Expressed in left testis and 15 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038873; CXorf66.
DR PANTHER; PTHR37340; PTHR37340; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..361
FT /note="Uncharacterized protein CXorf66"
FT /id="PRO_0000348434"
FT TOPO_DOM 20..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..361
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 99..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 233
FT /note="P -> L (in dbSNP:rs5955139)"
FT /id="VAR_046157"
SQ SEQUENCE 361 AA; 39944 MW; 3CC5814E66EA947C CRC64;
MNLVICVLLL SIWKNNCMTT NQTNGSSTTG DKPVESMQTK LNYLRRNLLI LVGIIIMVFV
FICFCYLHYN CLSDDASKAG MVKKKGIAAK SSKTSFSEAK TASQCSPETQ PMLSTADKSS
DSSSPERASA QSSTEKLIRP SSLQKPSIPN SAGKLTRPSY PKRSSKSSCS KKLSKSSHLE
KAHKKGSLEK LCKLDYACKL ASSDKPVRPP QLFKPLYSSH PQNEISPSKP FGPQELAKPP
KHFNPKRSVS LGRAALLSNS ELAETCQPYK KKHLVAKTYR PLVNDISEAK EKNTQNLHVS
SKVKSSSRSF RKLDSRNNAY GDHVNDSDTM KYYSEVDSDK VIIITCDRGY NQVTSEVTLN
D
