ID   CX111_DANRE             Reviewed;          94 AA.
AC   A0A0R4INB9;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=C-X-C motif chemokine 11-1 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=cxcl11.1 {ECO:0000312|ZFIN:ZDB-GENE-070907-2};
GN   Synonyms=cxcl11aa {ECO:0000303|PubMed:25573892};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN   [1] {ECO:0000312|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=25573892; DOI=10.1242/dmm.017756;
RA   Torraca V., Cui C., Boland R., Bebelman J.P., van der Sar A.M., Smit M.J.,
RA   Siderius M., Spaink H.P., Meijer A.H.;
RT   "The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and
RT   dissemination of mycobacterial infection.";
RL   Dis. Model. Mech. 8:253-269(2015).
CC   -!- FUNCTION: Ligand for cxcr3.2. Chemotactic for macrophages.
CC       {ECO:0000269|PubMed:25573892}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25573892}.
CC   -!- INDUCTION: Up-regulated in response to bacterial infection by
CC       S.typhimurium or M.marinum. {ECO:0000269|PubMed:25573892}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; BX323596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001339307.1; XM_001339271.6.
DR   AlphaFoldDB; A0A0R4INB9; -.
DR   SMR; A0A0R4INB9; -.
DR   Ensembl; ENSDART00000169606; ENSDARP00000135444; ENSDARG00000100662.
DR   GeneID; 798892; -.
DR   CTD; 798892; -.
DR   ZFIN; ZDB-GENE-070907-2; cxcl11.1.
DR   GeneTree; ENSGT01030000234997; -.
DR   OMA; GHMEVIA; -.
DR   OrthoDB; 1548456at2759; -.
DR   PRO; PR:A0A0R4INB9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000100662; Expressed in spleen and 7 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IDA:ZFIN.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..94
FT                   /note="C-X-C motif chemokine 11-1"
FT                   /id="PRO_5006451477"
FT   DISULFID        27..54
FT                   /evidence="ECO:0000250|UniProtKB:O14625"
FT   DISULFID        29..71
FT                   /evidence="ECO:0000250|UniProtKB:O14625"
SQ   SEQUENCE   94 AA;  10226 MW;  02F4446AE5B351D7 CRC64;
     MKTVTALLLV SLAVVAIEGQ HMKSQRCVCL GAGLNMVKPV LIEKIEILPS SPSCGHMEVI
     ATLKNGAGKR CLNPKSKFTK KIIDKIEKNN RNAR