ID   CX116_DANRE             Reviewed;         121 AA.
AC   B0R191;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=C-X-C motif chemokine 11-6 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=cxcl11.6 {ECO:0000312|ZFIN:ZDB-GENE-060526-78};
GN   Synonyms=cxcl11af {ECO:0000303|PubMed:25573892};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|Proteomes:UP000000437};
RN   [1] {ECO:0000312|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000312|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=25573892; DOI=10.1242/dmm.017756;
RA   Torraca V., Cui C., Boland R., Bebelman J.P., van der Sar A.M., Smit M.J.,
RA   Siderius M., Spaink H.P., Meijer A.H.;
RT   "The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and
RT   dissemination of mycobacterial infection.";
RL   Dis. Model. Mech. 8:253-269(2015).
CC   -!- FUNCTION: Ligand for cxcr3.2. Chemotactic for macrophages.
CC       {ECO:0000269|PubMed:25573892}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:25573892}.
CC   -!- INDUCTION: Up-regulated in response to bacterial infection by
CC       S.typhimurium or M.marinum. {ECO:0000269|PubMed:25573892}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; AL953908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005165468.1; XM_005165411.3.
DR   AlphaFoldDB; B0R191; -.
DR   SMR; B0R191; -.
DR   STRING; 7955.ENSDARP00000112794; -.
DR   PaxDb; B0R191; -.
DR   Ensembl; ENSDART00000138213; ENSDARP00000112794; ENSDARG00000094706.
DR   Ensembl; ENSDART00000181939; ENSDARP00000147964; ENSDARG00000093779.
DR   Ensembl; ENSDART00000183041; ENSDARP00000152492; ENSDARG00000116337.
DR   GeneID; 101883610; -.
DR   KEGG; dre:101883610; -.
DR   CTD; 101883610; -.
DR   ZFIN; ZDB-GENE-060526-78; cxcl11.6.
DR   eggNOG; ENOG502SGFE; Eukaryota.
DR   GeneTree; ENSGT00940000161751; -.
DR   HOGENOM; CLU_143902_2_1_1; -.
DR   InParanoid; B0R191; -.
DR   OMA; GHAIDNV; -.
DR   OrthoDB; 1548456at2759; -.
DR   PhylomeDB; B0R191; -.
DR   TreeFam; TF333433; -.
DR   PRO; PR:B0R191; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000093779; Expressed in spleen and 13 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IDA:ZFIN.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   2: Evidence at transcript level;
KW   Chemotaxis; Cytokine; Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..121
FT                   /note="C-X-C motif chemokine 11-6"
FT                   /id="PRO_5005122365"
FT   REGION          95..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        29..56
FT                   /evidence="ECO:0000250|UniProtKB:O14625"
FT   DISULFID        31..73
FT                   /evidence="ECO:0000250|UniProtKB:O14625"
SQ   SEQUENCE   121 AA;  13014 MW;  5939D2B6BEB4C0E8 CRC64;
     MKTLAAFLLL SCLIAGEVNG QDRSSRARCF CVDKGLNMVL LKNLDKVEIF PPSPSCNKHE
     IVVTLKNGAG QKCLNPDSKF TKNVVLKAIG KRMQQSVPHS TTTGTVKSSM TSSTSAPTAF
     K