CX172_ARATH
ID CX172_ARATH Reviewed; 72 AA.
AC Q94FT1; Q2HIR2; Q8LFR7;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Cytochrome c oxidase copper chaperone 2;
GN Name=COX17-2; OrderedLocusNames=At1g53030; ORFNames=F8L10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wintz H.;
RT "COX17-2, an A. thaliana copper chaperone.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Copper chaperone for cytochrome c oxidase (COX). Binds 2
CC copper ions and delivers them to the Cu(A) site of COX (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion intermembrane space.
CC -!- SIMILARITY: Belongs to the COX17 family. {ECO:0000305}.
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DR EMBL; AF349685; AAK73497.1; -; mRNA.
DR EMBL; AC022520; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE32879.1; -; Genomic_DNA.
DR EMBL; BT024519; ABD38858.1; -; mRNA.
DR EMBL; AY084685; AAM61247.1; -; mRNA.
DR RefSeq; NP_175711.1; NM_104181.5.
DR AlphaFoldDB; Q94FT1; -.
DR SMR; Q94FT1; -.
DR BioGRID; 26961; 1.
DR STRING; 3702.AT1G53030.1; -.
DR PaxDb; Q94FT1; -.
DR PRIDE; Q94FT1; -.
DR ProteomicsDB; 220510; -.
DR EnsemblPlants; AT1G53030.1; AT1G53030.1; AT1G53030.
DR GeneID; 841736; -.
DR Gramene; AT1G53030.1; AT1G53030.1; AT1G53030.
DR KEGG; ath:AT1G53030; -.
DR Araport; AT1G53030; -.
DR TAIR; locus:2037072; AT1G53030.
DR eggNOG; KOG3496; Eukaryota.
DR HOGENOM; CLU_149618_1_1_1; -.
DR InParanoid; Q94FT1; -.
DR OMA; KPLKACC; -.
DR OrthoDB; 1621529at2759; -.
DR PhylomeDB; Q94FT1; -.
DR PRO; PR:Q94FT1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94FT1; baseline and differential.
DR Genevisible; Q94FT1; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0016531; F:copper chaperone activity; IBA:GO_Central.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR InterPro; IPR009069; Cys_alpha_HP_mot_SF.
DR InterPro; IPR007745; Cyt_c_oxidase_Cu-chaperone.
DR PANTHER; PTHR16719; PTHR16719; 1.
DR Pfam; PF05051; COX17; 1.
DR SUPFAM; SSF47072; SSF47072; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 3: Inferred from homology;
KW Chaperone; Copper; Disulfide bond; Metal-binding; Mitochondrion;
KW Reference proteome.
FT CHAIN 1..72
FT /note="Cytochrome c oxidase copper chaperone 2"
FT /id="PRO_0000422759"
FT DOMAIN 32..72
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 35..45
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 54..64
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT BINDING 32
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:Q14061"
FT BINDING 33
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:Q14061"
FT DISULFID 35..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 45..54
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT CONFLICT 24
FT /note="E -> A (in Ref. 5; AAM61247)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="G -> S (in Ref. 4; ABD38858 and 5; AAM61247)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 72 AA; 7938 MW; 6DC281CFFE6A6272 CRC64;
MSGLQAQDSA CSLDKPSKDV VATETKPKKR ICCACPDTKK LRDECIVEHG ESACTKWIEA
HILCLRSEGF KV
