ID   CX21A_CONPU             Reviewed;          83 AA.
AC   P86500;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=Conotoxin p21a {ECO:0000303|PubMed:20564010};
OS   Conus purpurascens (Purple cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Chelyconus.
OX   NCBI_TaxID=41690;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SUBUNIT, MASS
RP   SPECTROMETRY, DISULFIDE BONDS, HYDROXYLATION AT PRO-24 AND PRO-43, AND
RP   AMIDATION AT HIS-83.
RC   TISSUE=Venom;
RX   PubMed=20564010; DOI=10.1002/bip.21406;
RA   Moller C., Mari F.;
RT   "9.3 kDa Components of the injected venom of Conus purpurascens define a
RT   new 5-disulfide conotoxin framework.";
RL   Biopolymers 96:158-165(2011).
CC   -!- SUBUNIT: May form a non-covalent dimer. {ECO:0000269|PubMed:20564010}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20564010}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:20564010}.
CC   -!- DOMAIN: The cysteine framework is XXI (CC-C-C-C-CC-C-C-C).
CC       {ECO:0000305}.
CC   -!- PTM: Contains 5 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=9320; Method=MALDI; Note=Average mass.;
CC       Evidence={ECO:0000269|PubMed:20564010};
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DR   AlphaFoldDB; P86500; -.
DR   SMR; P86500; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Secreted; Toxin.
FT   CHAIN           1..83
FT                   /note="Conotoxin p21a"
FT                   /evidence="ECO:0000269|PubMed:20564010"
FT                   /id="PRO_0000394442"
FT   MOD_RES         24
FT                   /note="4-hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:20564010"
FT   MOD_RES         43
FT                   /note="4-hydroxyproline; partial"
FT                   /evidence="ECO:0000269|PubMed:20564010"
FT   MOD_RES         83
FT                   /note="Histidine amide"
FT                   /evidence="ECO:0000269|PubMed:20564010"
SQ   SEQUENCE   83 AA;  9299 MW;  F3AFE939DE4153CD CRC64;
     FELLPSQDRS CCIQKTLECL ENYPGQASQR AHYCQQDATT NCPDTYYFGC CPGYATCMSI
     NAGNNVRSAF DKCINRLCFD PGH