ID   CX2A_CONBE              Reviewed;          30 AA.
AC   P58625;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Conotoxin Bt12.1 {ECO:0000305};
DE   AltName: Full=Conotoxin BeTXIIa {ECO:0000303|PubMed:10591037};
OS   Conus betulinus (Beech cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX   NCBI_TaxID=89764;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=10591037;
RA   Chen J.-S., Fan C.-X., Hu K.-P., Wei K.-H., Zhong M.-N.;
RT   "Studies on conotoxins of Conus betulinus.";
RL   J. Nat. Toxins 8:341-349(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XVIII (C-C-CC-CC).
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=3432.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10591037};
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DR   AlphaFoldDB; P58625; -.
DR   ConoServer; 1526; BeTXIIa.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..30
FT                   /note="Conotoxin Bt12.1"
FT                   /id="PRO_0000044511"
SQ   SEQUENCE   30 AA;  3438 MW;  0A03A29DFF47CEBB CRC64;
     RCAHGTYYSN DSQQCLLNCC WWGGGDHCCR