CX3C1_MOUSE
ID CX3C1_MOUSE Reviewed; 354 AA.
AC Q9Z0D9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=CX3C chemokine receptor 1 {ECO:0000303|PubMed:9918795};
DE Short=C-X3-C CKR-1 {ECO:0000303|PubMed:9918795};
DE Short=CX3CR1 {ECO:0000303|PubMed:9918795};
DE Short=mCX3CR1 {ECO:0000303|PubMed:9918795};
DE AltName: Full=Fractalkine receptor {ECO:0000303|PubMed:9918795};
GN Name=Cx3cr1 {ECO:0000303|PubMed:9918795};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=129/Sv;
RX PubMed=9918795; DOI=10.1006/bbrc.1998.9849;
RA Combadiere C., Gao J.-L., Tiffany H.L., Murphy P.M.;
RT "Gene cloning, RNA distribution, and functional expression of mCX3CR1, a
RT mouse chemotactic receptor for the CX3C chemokine fractalkine.";
RL Biochem. Biophys. Res. Commun. 253:728-732(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/SvJ;
RA Coultas L., McColl S.R.;
RT "Cloning and characterization of murine CX3CR1, a receptor for murine
RT fractalkine/neurotactin.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF 127-ASP-ARG-128 AND
RP ARG-128.
RX PubMed=10187784; DOI=10.1074/jbc.274.15.10053;
RA Haskell C.A., Cleary M.D., Charo I.F.;
RT "Molecular uncoupling of fractalkine-mediated cell adhesion and signal
RT transduction. Rapid flow arrest of CX3CR1-expressing cells is independent
RT of G-protein activation.";
RL J. Biol. Chem. 274:10053-10058(1999).
RN [5]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=10805752; DOI=10.1128/mcb.20.11.4106-4114.2000;
RA Jung S., Aliberti J., Graemmel P., Sunshine M.J., Kreutzberg G.W., Sher A.,
RA Littman D.R.;
RT "Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion
RT and green fluorescent protein reporter gene insertion.";
RL Mol. Cell. Biol. 20:4106-4114(2000).
RN [6]
RP FUNCTION.
RX PubMed=11544273; DOI=10.1172/jci12976;
RA Haskell C.A., Hancock W.W., Salant D.J., Gao W., Csizmadia V., Peters W.,
RA Faia K., Fituri O., Rottman J.B., Charo I.F.;
RT "Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac
RT allograft rejection.";
RL J. Clin. Invest. 108:679-688(2001).
RN [7]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12871640; DOI=10.1016/s1074-7613(03)00174-2;
RA Geissmann F., Jung S., Littman D.R.;
RT "Blood monocytes consist of two principal subsets with distinct migratory
RT properties.";
RL Immunity 19:71-82(2003).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12569158; DOI=10.1172/jci200315555;
RA Lesnik P., Haskell C.A., Charo I.F.;
RT "Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine
RT in atherogenesis.";
RL J. Clin. Invest. 111:333-340(2003).
RN [9]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15653504; DOI=10.1126/science.1102901;
RA Niess J.H., Brand S., Gu X., Landsman L., Jung S., McCormick B.A.,
RA Vyas J.M., Boes M., Ploegh H.L., Fox J.G., Littman D.R., Reinecker H.C.;
RT "CX3CR1-mediated dendritic cell access to the intestinal lumen and
RT bacterial clearance.";
RL Science 307:254-258(2005).
RN [10]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16675847; DOI=10.1096/fj.05-5465com;
RA Huang D., Shi F.D., Jung S., Pien G.C., Wang J., Salazar-Mather T.P.,
RA He T.T., Weaver J.T., Ljunggren H.G., Biron C.A., Littman D.R.,
RA Ransohoff R.M.;
RT "The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells
RT that modify experimental autoimmune encephalomyelitis within the central
RT nervous system.";
RL FASEB J. 20:896-905(2006).
RN [11]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=16732273; DOI=10.1038/nn1715;
RA Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M.,
RA Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., Lee J.C.,
RA Cook D.N., Jung S., Lira S.A., Littman D.R., Ransohoff R.M.;
RT "Control of microglial neurotoxicity by the fractalkine receptor.";
RL Nat. Neurosci. 9:917-924(2006).
RN [12]
RP FUNCTION.
RX PubMed=18322241; DOI=10.4049/jimmunol.180.6.4283;
RA Lu P., Li L., Kuno K., Wu Y., Baba T., Li Y.Y., Zhang X., Mukaida N.;
RT "Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-
RT induced corneal neovascularization through enhanced antiangiogenic factor
RT expression.";
RL J. Immunol. 180:4283-4291(2008).
RN [13]
RP FUNCTION.
RX PubMed=18971423; DOI=10.1182/blood-2008-07-170787;
RA Landsman L., Bar-On L., Zernecke A., Kim K.W., Krauthgamer R.,
RA Shagdarsuren E., Lira S.A., Weissman I.L., Weber C., Jung S.;
RT "CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting
RT cell survival.";
RL Blood 113:963-972(2009).
RN [14]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-345, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [15]
RP FUNCTION.
RX PubMed=21037587; DOI=10.1038/nm.2253;
RA Mionnet C., Buatois V., Kanda A., Milcent V., Fleury S., Lair D.,
RA Langelot M., Lacoeuille Y., Hessel E., Coffman R., Magnan A.,
RA Dombrowicz D., Glaichenhaus N., Julia V.;
RT "CX3CR1 is required for airway inflammation by promoting T helper cell
RT survival and maintenance in inflamed lung.";
RL Nat. Med. 16:1305-1312(2010).
RN [16]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21778362; DOI=10.1126/science.1202529;
RA Paolicelli R.C., Bolasco G., Pagani F., Maggi L., Scianni M.,
RA Panzanelli P., Giustetto M., Ferreira T.A., Guiducci E., Dumas L.,
RA Ragozzino D., Gross C.T.;
RT "Synaptic pruning by microglia is necessary for normal brain development.";
RL Science 333:1456-1458(2011).
RN [17]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=24487234; DOI=10.1038/nn.3641;
RA Zhan Y., Paolicelli R.C., Sforazzini F., Weinhard L., Bolasco G.,
RA Pagani F., Vyssotski A.L., Bifone A., Gozzi A., Ragozzino D., Gross C.T.;
RT "Deficient neuron-microglia signaling results in impaired functional brain
RT connectivity and social behavior.";
RL Nat. Neurosci. 17:400-406(2014).
RN [18]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=29326275; DOI=10.1126/science.aao1503;
RA Leonardi I., Li X., Semon A., Li D., Doron I., Putzel G., Bar A.,
RA Prieto D., Rescigno M., McGovern D.P.B., Pla J., Iliev I.D.;
RT "CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.";
RL Science 359:232-236(2018).
RN [19]
RP FUNCTION.
RX PubMed=33548172; DOI=10.1016/j.cell.2021.01.016;
RA Doron I., Leonardi I., Li X.V., Fiers W.D., Semon A., Bialt-DeCelie M.,
RA Migaud M., Gao I.H., Lin W.Y., Kusakabe T., Puel A., Iliev I.D.;
RT "Human gut mycobiota tune immunity via CARD9-dependent induction of anti-
RT fungal IgG antibodies.";
RL Cell 0:0-0(2021).
CC -!- FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1)
CC present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts
CC distinct functions in different tissue compartments, such as immune
CC response, inflammation, cell adhesion and chemotaxis (PubMed:9918795,
CC PubMed:10187784). CX3CR1-CX3CL1 signaling mediates cell migratory
CC functions (PubMed:11544273, PubMed:12871640, PubMed:16675847,
CC PubMed:18322241). Responsible for the recruitment of natural killer
CC (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts
CC as a regulator of inflammation process leading to atherogenesis by
CC mediating macrophage and monocyte recruitment to inflamed
CC atherosclerotic plaques, promoting cell survival (PubMed:12569158,
CC PubMed:18971423). Involved in airway inflammation by promoting
CC interleukin 2-producing T helper (Th2) cell survival in inflamed lung
CC (PubMed:21037587). Involved in the migration of circulating monocytes
CC to non-inflamed tissues, where they differentiate into macrophages and
CC dendritic cells (PubMed:12871640). Acts as a negative regulator of
CC angiogenesis, probably by promoting macrophage chemotaxis
CC (PubMed:18322241). Plays a key role in brain microglia by regulating
CC inflammatory response in the central nervous system (CNS) and
CC regulating synapse maturation (PubMed:16732273, PubMed:21778362,
CC PubMed:24487234). Required to restrain the microglial inflammatory
CC response in the CNS and the resulting parenchymal damage in response to
CC pathological stimuli (PubMed:16732273). Involved in brain development
CC by participating in synaptic pruning, a natural process during which
CC brain microglia eliminates extra synapses during postnatal development
CC (PubMed:21778362). Synaptic pruning by microglia is required to promote
CC the maturation of circuit connectivity during brain development
CC (PubMed:24487234). Acts as an important regulator of the gut microbiota
CC by controlling immunity to intestinal bacteria and fungi
CC (PubMed:15653504, PubMed:29326275). Expressed in lamina propria
CC dendritic cells in the small intestine, which form transepithelial
CC dendrites capable of taking up bacteria in order to provide defense
CC against pathogenic bacteria (PubMed:15653504). Required to initiate
CC innate and adaptive immune responses against dissemination of commensal
CC fungi (mycobiota) component of the gut: expressed in mononuclear
CC phagocytes (MNPs) and acts by promoting induction of antifungal IgG
CC antibodies response to confer protection against disseminated
CC C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172).
CC Also acts as a receptor for C-C motif chemokine CCL26, inducing cell
CC chemotaxis (By similarity). {ECO:0000250|UniProtKB:P49238,
CC ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:11544273,
CC ECO:0000269|PubMed:12569158, ECO:0000269|PubMed:12871640,
CC ECO:0000269|PubMed:15653504, ECO:0000269|PubMed:16675847,
CC ECO:0000269|PubMed:16732273, ECO:0000269|PubMed:18322241,
CC ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:21037587,
CC ECO:0000269|PubMed:21778362, ECO:0000269|PubMed:24487234,
CC ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:33548172,
CC ECO:0000269|PubMed:9918795}.
CC -!- SUBUNIT: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or
CC ITGA4:ITGB1. {ECO:0000250|UniProtKB:P49238}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10187784};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in subsets of leukocytes:
CC expressed in monocytes, subsets of T-cells and natural killer (NK)
CC cells in the circulation, dendritic cells, as well as in microglia in
CC the central nervous system (CNS) (PubMed:10805752, PubMed:12871640,
CC PubMed:16732273). Expression level subdivides blood monocytes into two
CC major functional subsets; CD14(+)CD16(-)-CX3CR1(low) inflammatory
CC monocytes and CD14(low)CD16(+)CX3CR1(high) homeostatic monocytes
CC (PubMed:12871640). Expressed in myeloid-derived mucosal dendritic
CC cells, which populate the entire lamina propria of the small intestine
CC (PubMed:15653504). {ECO:0000269|PubMed:10805752,
CC ECO:0000269|PubMed:12871640, ECO:0000269|PubMed:15653504,
CC ECO:0000269|PubMed:16732273}.
CC -!- PTM: This protein is not N-glycosylated which is unusual for G-protein-
CC coupled receptors. {ECO:0000250|UniProtKB:P35411}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype in normal conditions; mice
CC develop normally and are fertile (PubMed:10805752). Mice lacking both
CC Cx3cr1 and Apoe show decreased atherogenesis (PubMed:12569158). In
CC experimental autoimmune encephalomyelitis (EAE) model mice, recruitment
CC of natural killer (NK) cells in the inflamed central nervous system
CC (CNS) is impaired, leading to increased EAE-related mortality,
CC nonremitting spastic paraplegia and hemorrhagic inflammatory lesions
CC (PubMed:16675847). Mice show an increased microglial inflammatory
CC response and neuronal death in several models of CNS insult
CC (PubMed:16732273). Mice display reduced airway inflammation in lung
CC after allergen sensitization (PubMed:21037587). Mice display a
CC transient decrease in microglia density, leading to synaptic deficits
CC characterized by an excess of weak excitatory synapses: defects are
CC caused by a failure to eliminate immature synaptic connections during
CC the second and third postnatal weeks (PubMed:21778362). Deficient
CC synaptic pruning is associated with weak synaptic transmission,
CC decreased functional brain connectivity, deficits in social interaction
CC and increased repetitive-behavior phenotypes (PubMed:24487234). Defects
CC of lamina propria dendritic cells are observed, leading to impair the
CC sampling of bacteria from the intestinal lumen and affect their ability
CC to take up invasive pathogens (PubMed:15653504). Mice are more
CC susceptible to severe colitis that is rescued by antifungal treatment
CC and display changes in gut fungal communities (PubMed:29326275).
CC {ECO:0000269|PubMed:10805752, ECO:0000269|PubMed:12569158,
CC ECO:0000269|PubMed:15653504, ECO:0000269|PubMed:16675847,
CC ECO:0000269|PubMed:16732273, ECO:0000269|PubMed:21037587,
CC ECO:0000269|PubMed:21778362, ECO:0000269|PubMed:24487234,
CC ECO:0000269|PubMed:29326275}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF074912; AAD08665.1; -; Genomic_DNA.
DR EMBL; AF102269; AAC72408.1; -; mRNA.
DR EMBL; BC012653; AAH12653.1; -; mRNA.
DR CCDS; CCDS40806.1; -.
DR RefSeq; NP_034117.3; NM_009987.4.
DR AlphaFoldDB; Q9Z0D9; -.
DR SMR; Q9Z0D9; -.
DR STRING; 10090.ENSMUSP00000063986; -.
DR iPTMnet; Q9Z0D9; -.
DR PhosphoSitePlus; Q9Z0D9; -.
DR SwissPalm; Q9Z0D9; -.
DR PaxDb; Q9Z0D9; -.
DR PRIDE; Q9Z0D9; -.
DR ProteomicsDB; 285403; -.
DR Antibodypedia; 6554; 779 antibodies from 46 providers.
DR DNASU; 13051; -.
DR Ensembl; ENSMUST00000064165; ENSMUSP00000063986; ENSMUSG00000052336.
DR Ensembl; ENSMUST00000177637; ENSMUSP00000136413; ENSMUSG00000052336.
DR Ensembl; ENSMUST00000215016; ENSMUSP00000150463; ENSMUSG00000052336.
DR GeneID; 13051; -.
DR KEGG; mmu:13051; -.
DR UCSC; uc009sbz.2; mouse.
DR CTD; 1524; -.
DR MGI; MGI:1333815; Cx3cr1.
DR VEuPathDB; HostDB:ENSMUSG00000052336; -.
DR eggNOG; ENOG502QVQK; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q9Z0D9; -.
DR OMA; FRKYLYH; -.
DR OrthoDB; 900867at2759; -.
DR PhylomeDB; Q9Z0D9; -.
DR TreeFam; TF330966; -.
DR Reactome; R-MMU-380108; Chemokine receptors bind chemokines.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR BioGRID-ORCS; 13051; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Cx3cr1; mouse.
DR PRO; PR:Q9Z0D9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9Z0D9; protein.
DR Bgee; ENSMUSG00000052336; Expressed in lumbar subsegment of spinal cord and 176 other tissues.
DR ExpressionAtlas; Q9Z0D9; baseline and differential.
DR Genevisible; Q9Z0D9; MM.
DR GO; GO:0009986; C:cell surface; IDA:ARUK-UCL.
DR GO; GO:0097447; C:dendritic tree; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0032809; C:neuronal cell body membrane; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019960; F:C-X3-C chemokine binding; IPI:ARUK-UCL.
DR GO; GO:0016495; F:C-X3-C chemokine receptor activity; IDA:UniProtKB.
DR GO; GO:0004950; F:chemokine receptor activity; ISO:MGI.
DR GO; GO:0031737; F:CX3C chemokine receptor binding; ISO:MGI.
DR GO; GO:0004896; F:cytokine receptor activity; IMP:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:ARUK-UCL.
DR GO; GO:0002250; P:adaptive immune response; IMP:UniProtKB.
DR GO; GO:0061760; P:antifungal innate immune response; IMP:UniProtKB.
DR GO; GO:0035425; P:autocrine signaling; ISO:MGI.
DR GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IPI:ARUK-UCL.
DR GO; GO:0060326; P:cell chemotaxis; ISO:MGI.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IGI:ARUK-UCL.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR GO; GO:0021626; P:central nervous system maturation; IMP:ARUK-UCL.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; ISO:MGI.
DR GO; GO:0006935; P:chemotaxis; ISO:MGI.
DR GO; GO:0048874; P:host-mediated regulation of intestinal microbiota composition; IMP:UniProtKB.
DR GO; GO:0006955; P:immune response; IMP:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IC:ARUK-UCL.
DR GO; GO:0030595; P:leukocyte chemotaxis; IMP:UniProtKB.
DR GO; GO:0050901; P:leukocyte tethering or rolling; IGI:ARUK-UCL.
DR GO; GO:0007613; P:memory; ISO:MGI.
DR GO; GO:0001774; P:microglial cell activation; ISO:MGI.
DR GO; GO:0002282; P:microglial cell activation involved in immune response; IMP:UniProtKB.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IMP:ARUK-UCL.
DR GO; GO:0150090; P:multiple spine synapse organization, single dendrite; IMP:ARUK-UCL.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR GO; GO:0002881; P:negative regulation of chronic inflammatory response to non-antigenic stimulus; ISO:MGI.
DR GO; GO:0110091; P:negative regulation of hippocampal neuron apoptotic process; ISO:MGI.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; ISO:MGI.
DR GO; GO:1900272; P:negative regulation of long-term synaptic potentiation; ISO:MGI.
DR GO; GO:1904150; P:negative regulation of microglial cell mediated cytotoxicity; IMP:UniProtKB.
DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IMP:ARUK-UCL.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:1903721; P:positive regulation of I-kappaB phosphorylation; ISO:MGI.
DR GO; GO:1904141; P:positive regulation of microglial cell migration; ISO:MGI.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IMP:UniProtKB.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; ISO:MGI.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ARUK-UCL.
DR GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
DR GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; IGI:ARUK-UCL.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IGI:ARUK-UCL.
DR GO; GO:0002931; P:response to ischemia; ISO:MGI.
DR GO; GO:0035176; P:social behavior; IMP:ARUK-UCL.
DR GO; GO:0060074; P:synapse maturation; IMP:ARUK-UCL.
DR GO; GO:0098883; P:synapse pruning; IMP:UniProtKB.
DR InterPro; IPR005387; Chemokine_CX3CR1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01562; FRACTALKINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Immunity; Inflammatory response;
KW Innate immunity; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..354
FT /note="CX3C chemokine receptor 1"
FT /id="PRO_0000069327"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..143
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 345
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT DISULFID 103..176
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT MUTAGEN 127..128
FT /note="DR->NN: In DR/NN; abolished activity without
FT affecting avility to bind CX3CL1."
FT /evidence="ECO:0000269|PubMed:10187784"
FT MUTAGEN 128
FT /note="R->N: Abolished activity without affecting avility
FT to bind CX3CL1."
FT /evidence="ECO:0000269|PubMed:10187784"
SQ SEQUENCE 354 AA; 40266 MW; 12C745E8E3755CA9 CRC64;
MSTSFPELDL ENFEYDDSAE ACYLGDIVAF GTIFLSVFYA LVFTFGLVGN LLVVLALTNS
RKPKSITDIY LLNLALSDLL FVATLPFWTH YLISHEGLHN AMCKLTTAFF FIGFFGGIFF
ITVISIDRYL AIVLAANSMN NRTVQHGVTI SLGVWAAAIL VASPQFMFTK RKDNECLGDY
PEVLQEMWPV LRNSEVNILG FALPLLIMSF CYFRIIQTLF SCKNRKKARA VRLILLVVFA
FFLFWTPYNI MIFLETLKFY NFFPSCDMKR DLRLALSVTE TVAFSHCCLN PFIYAFAGEK
FRRYLGHLYR KCLAVLCGHP VHTGFSPESQ RSRQDSILSS FTHYTSEGDG SLLL
