ID   CX5E_CONTE              Reviewed;          14 AA.
AC   P0DPK7;
DT   12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 1.
DT   29-SEP-2021, entry version 6.
DE   RecName: Full=Conotoxin tx5e {ECO:0000305};
OS   Conus textile (Cloth-of-gold cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=6494;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT LEU-14, IDENTIFICATION BY MASS SPECTROMETRY,
RP   TISSUE SPECIFICITY, POSITION IN VENOM DUCT, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=23031820; DOI=10.1016/j.toxicon.2012.09.013;
RA   Dobson R., Collodoro M., Gilles N., Turtoi A., De Pauw E., Quinton L.;
RT   "Secretion and maturation of conotoxins in the venom ducts of Conus
RT   textile.";
RL   Toxicon 60:1370-1379(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23031820}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. Is present in all duct
CC       parts with a highest content in part 2 (proximal of the venom bulb) and
CC       then decreases in concentration toward the end of the duct.
CC       {ECO:0000305|PubMed:23031820}.
CC   -!- DOMAIN: The cysteine framework is V (CC-CC). {ECO:0000305}.
CC   -!- PTM: Contains 2 disulfide bonds that can be either 'C1-C3, C2-C4' or
CC       'C1-C4, C2-C3', since these disulfide connectivities have been observed
CC       for conotoxins with cysteine framework V (for examples, see AC P0DQQ7
CC       and AC P81755). {ECO:0000305}.
CC   -!- MISCELLANEOUS: The name has been given by ConoServer. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..14
FT                   /note="Conotoxin tx5e"
FT                   /evidence="ECO:0000269|PubMed:23031820"
FT                   /id="PRO_0000445010"
FT   MOD_RES         14
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:23031820"
SQ   SEQUENCE   14 AA;  1480 MW;  E10C9F33787E5AA1 CRC64;
     PCCSKLHDNS CCGL