ID   CX67_CONAA              Reviewed;          58 AA.
AC   A0A3G3C7W0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-FEB-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Conotoxin Am6.7 {ECO:0000305};
DE   Flags: Precursor; Fragment;
OS   Conus amadis (Amadis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX   NCBI_TaxID=198732;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-58, SUBCELLULAR
RP   LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30593932; DOI=10.1016/j.jprot.2018.12.028;
RA   Vijayasarathy M., Balaram P.;
RT   "Cone snail prolyl-4-hydroxylase alpha-subunit sequences derived from
RT   transcriptomic data and mass spectrometric analysis of variable proline
RT   hydroxylation in C. amadis venom.";
RL   J. Proteomics 194:37-48(2019).
CC   -!- FUNCTION: Probable toxin that inhibits ion channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30593932}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30593932}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000305}.
CC   -!- PTM: Mostly non-hydroxylated. {ECO:0000269|PubMed:30593932}.
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DR   EMBL; MH282828; AYP73035.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Knottin; Secreted; Toxin.
FT   PROPEP          <1..25
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000453605"
FT   PEPTIDE         26..58
FT                   /note="Conotoxin Am6.7"
FT                   /evidence="ECO:0000269|PubMed:30593932"
FT                   /id="PRO_0000453606"
FT   DISULFID        26..40
FT                   /evidence="ECO:0000305"
FT   DISULFID        33..44
FT                   /evidence="ECO:0000305"
FT   DISULFID        39..57
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AYP73035.1"
SQ   SEQUENCE   58 AA;  6987 MW;  A7CB17A06D5EF7D8 CRC64;
     WRKTPEGADR TFLQQECYQE IRQKRCRTVG RPCHYSAQCC SDFCAHTISN YYYIKRCS