ID   CX69_CONCB              Reviewed;          14 AA.
AC   P0DQN0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   02-DEC-2020, entry version 2.
DE   RecName: Full=Conotoxin Cca1669 {ECO:0000303|PubMed:32234761};
OS   Conus caracteristicus (Characteristic cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus.
OX   NCBI_TaxID=89440;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT GLY-14, AND SYNTHESIS OF NON-AMIDATED AND
RP   AMIDATED PEPTIDE.
RX   PubMed=32234761; DOI=10.1074/jbc.ra119.012098;
RA   Mohan M.K., Abraham N., Rajesh P.R., Jayaseelan B.F., Ragnarsson L.,
RA   Lewis R.J., Sarma S.P.;
RT   "Structure and allosteric activity of a single-disulfide conopeptide from
RT   Conus zonatus at human alpha3beta4 and alpha7 nicotinic acetylcholine
RT   receptors.";
RL   J. Biol. Chem. 295:7096-7112(2020).
CC   -!- FUNCTION: Probable toxin. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32234761}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:32234761}.
CC   -!- DOMAIN: The cysteine framework is C-C. {ECO:0000305}.
CC   -!- PTM: Amidation at Gly-14 does not impact activity, since a non-amidated
CC       synthetic peptide shows the same absence of activity than the natural
CC       amidated peptide. {ECO:0000269|PubMed:32234761}.
CC   -!- MISCELLANEOUS: Does not modulate oxytocin (OXTR), vasopressin (AVPR1A
CC       and AVPR1B), NMDA (GRIN1 and GRIN2A), muscarinic (CHRM1 and CHRM3), and
CC       nicotinic acetylcholine receptors (alpha-7, and alpha-3-beta-4), and
CC       voltage-gated calcium (Cav) and sodium channels (Nav).
CC       {ECO:0000269|PubMed:32234761}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Secreted; Toxin.
FT   PEPTIDE         1..14
FT                   /note="Conotoxin Cca1669"
FT                   /evidence="ECO:0000269|PubMed:32234761"
FT                   /id="PRO_0000450819"
FT   MOD_RES         14
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:32234761"
FT   DISULFID        3..7
FT                   /evidence="ECO:0000269|PubMed:32234761"
SQ   SEQUENCE   14 AA;  1672 MW;  9812D3A87008811E CRC64;
     RDCGKMCEEE TWKG