CX6A_CONIM
ID CX6A_CONIM Reviewed; 74 AA.
AC A0A125S9G3;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2016, sequence version 1.
DT 25-MAY-2022, entry version 9.
DE RecName: Full=Conotoxin Im6.10 {ECO:0000305};
DE AltName: Full=Conopeptide im029 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17687.1};
DE Flags: Precursor;
OS Conus imperialis (Imperial cone).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX NCBI_TaxID=35631;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Venom, and Venom duct;
RX PubMed=30893765; DOI=10.3390/md17030177;
RA Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA Alewood P.F.;
RT "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT cone snail, Conus imperialis.";
RL Mar. Drugs 17:0-0(2019).
CC -!- FUNCTION: Probable neurotoxin. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC {ECO:0000305|PubMed:30893765}.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000305}.
CC -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KT377423; AME17687.1; -; mRNA.
DR AlphaFoldDB; A0A125S9G3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Disulfide bond; Neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT PROPEP 20..47
FT /evidence="ECO:0000305"
FT /id="PRO_0000451009"
FT PEPTIDE 48..74
FT /note="Conotoxin Im6.10"
FT /id="PRO_5007179698"
FT DISULFID 49..58
FT /evidence="ECO:0000305"
FT DISULFID 52..63
FT /evidence="ECO:0000305"
FT DISULFID 57..73
FT /evidence="ECO:0000305"
SQ SEQUENCE 74 AA; 8066 MW; E9129FA450409E54 CRC64;
MKTGMIICLL LIAFMDADGS PGDTLYSQKT ADTDSGMKRF QKTFQKRRCV FCPKEPCCDG
DQCMTAPGTG PFCG