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CX6B2_BOVIN
ID   CX6B2_BOVIN             Reviewed;          88 AA.
AC   Q6YFP9; Q32KV3;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cytochrome c oxidase subunit 6B2;
DE   AltName: Full=Cytochrome c oxidase subunit VIb isoform 2;
DE            Short=COX VIb-2;
DE   AltName: Full=Cytochrome c oxidase subunit VIb, testis-specific isoform;
GN   Name=COX6B2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=12874793; DOI=10.1002/mrd.10327;
RA   Huttemann M., Jaradat S., Grossman L.I.;
RT   "Cytochrome c oxidase of mammals contains a testes-specific isoform of
RT   subunit VIb -- the counterpart to testes-specific cytochrome c?";
RL   Mol. Reprod. Dev. 66:8-16(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC       mitochondrial electron transport chain which drives oxidative
CC       phosphorylation. The respiratory chain contains 3 multisubunit
CC       complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC       cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC       CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC       transfer electrons derived from NADH and succinate to molecular oxygen,
CC       creating an electrochemical gradient over the inner membrane that
CC       drives transmembrane transport and the ATP synthase. Cytochrome c
CC       oxidase is the component of the respiratory chain that catalyzes the
CC       reduction of oxygen to water. Electrons originating from reduced
CC       cytochrome c in the intermembrane space (IMS) are transferred via the
CC       dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC       to the active site in subunit 1, a binuclear center (BNC) formed by
CC       heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC       water molecules using 4 electrons from cytochrome c in the IMS and 4
CC       protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:Q01519}.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC       {ECO:0000250|UniProtKB:Q01519}.
CC   -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC       multisubunit enzyme composed of 14 subunits. The complex is composed of
CC       a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC       the mitochondrial DNA, and 11 supernumerary subunits COX4I1 (or
CC       COX4I2), COX5A, COX5B, COX6A2 (or COX6A1), COX6B1 (or COX6B2), COX6C,
CC       COX7A1 (or COX7A2), COX7B, COX7C, COX8B and NDUFA4, which are encoded
CC       in the nuclear genome (By similarity). The complex exists as a monomer
CC       or a dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC       membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC       ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC       III, CIII), resulting in different assemblies (supercomplex
CC       SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)) (By similarity).
CC       {ECO:0000250|UniProtKB:P00429}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P00429}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P00429}; Intermembrane side
CC       {ECO:0000250|UniProtKB:P00429}.
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase subunit 6B family.
CC       {ECO:0000305}.
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DR   EMBL; AY152401; AAN46754.1; -; mRNA.
DR   EMBL; BC109911; AAI09912.1; -; mRNA.
DR   RefSeq; NP_001012702.1; NM_001012684.1.
DR   RefSeq; XP_005219732.1; XM_005219675.3.
DR   AlphaFoldDB; Q6YFP9; -.
DR   SMR; Q6YFP9; -.
DR   STRING; 9913.ENSBTAP00000009474; -.
DR   PaxDb; Q6YFP9; -.
DR   PRIDE; Q6YFP9; -.
DR   Ensembl; ENSBTAT00000009474; ENSBTAP00000009474; ENSBTAG00000007200.
DR   GeneID; 503554; -.
DR   KEGG; bta:503554; -.
DR   CTD; 125965; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007200; -.
DR   VGNC; VGNC:27638; COX6B2.
DR   eggNOG; KOG3057; Eukaryota.
DR   GeneTree; ENSGT00940000162621; -.
DR   HOGENOM; CLU_133964_3_1_1; -.
DR   InParanoid; Q6YFP9; -.
DR   OMA; VQRWNQQ; -.
DR   OrthoDB; 1586678at2759; -.
DR   TreeFam; TF105065; -.
DR   UniPathway; UPA00705; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000007200; Expressed in spermatocyte and 73 other tissues.
DR   ExpressionAtlas; Q6YFP9; baseline and differential.
DR   GO; GO:0030061; C:mitochondrial crista; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0045277; C:respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00926; Cyt_c_Oxidase_VIb; 1.
DR   Gene3D; 1.10.10.140; -; 1.
DR   InterPro; IPR003213; Cyt_c_oxidase_su6B.
DR   InterPro; IPR036549; Cyt_c_oxidase_su6B_sf.
DR   PANTHER; PTHR11387; PTHR11387; 1.
DR   Pfam; PF02297; COX6B; 1.
DR   PIRSF; PIRSF000278; Cyt_c_oxidase_6B; 1.
DR   SUPFAM; SSF47694; SSF47694; 1.
DR   PROSITE; PS51808; CHCH; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome.
FT   CHAIN           1..88
FT                   /note="Cytochrome c oxidase subunit 6B2"
FT                   /id="PRO_0000194920"
FT   DOMAIN          29..75
FT                   /note="CHCH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           32..42
FT                   /note="Cx9C motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   MOTIF           56..67
FT                   /note="Cx10C motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        32..67
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT   CONFLICT        58
FT                   /note="Y -> S (in Ref. 2; AAI09912)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   88 AA;  10533 MW;  50C2B34F99912487 CRC64;
     MLGAECPKPC KGKWPTPPFD PRFPNQNQTR NCYQNFLDYH RCIKTMNRRG KSTQPCEYYF
     RVYHSLCPIS WVQRWKEQIK DGTFAGKI
 
 
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