CX7A1_MOUSE
ID CX7A1_MOUSE Reviewed; 80 AA.
AC P56392;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Cytochrome c oxidase subunit 7A1, mitochondrial;
DE AltName: Full=Cytochrome c oxidase subunit VIIa-heart;
DE Short=Cytochrome c oxidase subunit VIIa-H;
DE AltName: Full=Cytochrome c oxidase subunit VIIa-muscle;
DE Short=Cytochrome c oxidase subunit VIIa-M;
DE Flags: Precursor;
GN Name=Cox7a1; Synonyms=Cox7a, Cox7ah;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Marra M., Hillier L., Allen M., Bowles M., Dietrich N., Dubuque T.,
RA Geisel S., Kucaba T., Lacy M., Le M., Martin J., Morris M.,
RA Schellenberg K., Steptoe M., Tan F., Underwood K., Moore B., Theising B.,
RA Wylie T., Lennon G., Soares B., Wilson R., Waterston R.;
RL Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9615220; DOI=10.1006/geno.1998.5279;
RA Jaradat S.A., Ko M.S., Grossman L.I.;
RT "Tissue-specific expression and mapping of the Cox7ah gene in mouse.";
RL Genomics 49:363-370(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10174}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P10174}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC are encoded in the nuclear genome. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC {ECO:0000250|UniProtKB:P07470}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P07470}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P07470}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIa family.
CC {ECO:0000305}.
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DR EMBL; AA027520; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA444750; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AA218039; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF037370; AAC23485.1; -; mRNA.
DR EMBL; BC060974; AAH60974.1; -; mRNA.
DR CCDS; CCDS21081.1; -.
DR RefSeq; NP_034074.1; NM_009944.3.
DR AlphaFoldDB; P56392; -.
DR SMR; P56392; -.
DR BioGRID; 198846; 2.
DR IntAct; P56392; 1.
DR STRING; 10090.ENSMUSP00000096193; -.
DR iPTMnet; P56392; -.
DR PhosphoSitePlus; P56392; -.
DR jPOST; P56392; -.
DR PaxDb; P56392; -.
DR PeptideAtlas; P56392; -.
DR PRIDE; P56392; -.
DR ProteomicsDB; 283983; -.
DR Antibodypedia; 44654; 104 antibodies from 22 providers.
DR DNASU; 12865; -.
DR Ensembl; ENSMUST00000098594; ENSMUSP00000096193; ENSMUSG00000074218.
DR GeneID; 12865; -.
DR KEGG; mmu:12865; -.
DR UCSC; uc009gdp.1; mouse.
DR CTD; 1346; -.
DR MGI; MGI:1316714; Cox7a1.
DR VEuPathDB; HostDB:ENSMUSG00000074218; -.
DR eggNOG; ENOG502SBK9; Eukaryota.
DR GeneTree; ENSGT00940000162305; -.
DR HOGENOM; CLU_173437_1_0_1; -.
DR InParanoid; P56392; -.
DR OrthoDB; 1548349at2759; -.
DR PhylomeDB; P56392; -.
DR TreeFam; TF105067; -.
DR UniPathway; UPA00705; -.
DR BioGRID-ORCS; 12865; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Cox7a1; mouse.
DR PRO; PR:P56392; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P56392; protein.
DR Bgee; ENSMUSG00000074218; Expressed in myocardium of ventricle and 168 other tissues.
DR ExpressionAtlas; P56392; baseline and differential.
DR Genevisible; P56392; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005746; C:mitochondrial respirasome; IBA:GO_Central.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; ISS:UniProtKB.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR GO; GO:0002082; P:regulation of oxidative phosphorylation; IBA:GO_Central.
DR CDD; cd00928; Cyt_c_Oxidase_VIIa; 1.
DR Gene3D; 4.10.91.10; -; 1.
DR InterPro; IPR039297; COX7a.
DR InterPro; IPR036539; Cyt_c_oxidase_su7a_sf.
DR InterPro; IPR003177; Cytc_oxidase_su7a_met.
DR PANTHER; PTHR10510; PTHR10510; 1.
DR Pfam; PF02238; COX7a; 1.
DR SUPFAM; SSF81419; SSF81419; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..21
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:P07470"
FT CHAIN 22..80
FT /note="Cytochrome c oxidase subunit 7A1, mitochondrial"
FT /id="PRO_0000006150"
FT TOPO_DOM 22..46
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P07470"
FT TRANSMEM 47..75
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P07470"
FT TOPO_DOM 76..80
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P07470"
SQ SEQUENCE 80 AA; 8986 MW; 9C6FB6C8E6E4C340 CRC64;
MRALRVSQAL VRSFSSSTRS HLENRVAEKQ KLFQADNDLP VHLKGGGMDN VLYRLTMTLT
LGGTAYCLYC LGWASFPHKK
