CX7B2_HUMAN
ID CX7B2_HUMAN Reviewed; 81 AA.
AC Q8TF08; Q32Q40;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cytochrome c oxidase subunit 7B2, mitochondrial;
DE AltName: Full=Cytochrome c oxidase polypeptide VIIb2;
DE Flags: Precursor;
GN Name=COX7B2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Jin L., Yu L., Zhao S.Y.;
RT "Cloning of a new human cDNA similar to Homo sapiens coxVIIb mRNA.";
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT GLN-27.
RX PubMed=15623157; DOI=10.1360/03yc0037;
RA Liang H., Chen H., Shen Y., Feng Q., Jin W., Huang W., Zeng Y.;
RT "A rare polymorphism of the COX7B2 gene in a Cantonese family with
RT nasopharyngeal carcinoma.";
RL Sci. China, Ser. C, Life Sci. 47:449-453(2004).
CC -!- FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the
CC mitochondrial electron transport chain which drives oxidative
CC phosphorylation. The respiratory chain contains 3 multisubunit
CC complexes succinate dehydrogenase (complex II, CII), ubiquinol-
CC cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III,
CC CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to
CC transfer electrons derived from NADH and succinate to molecular oxygen,
CC creating an electrochemical gradient over the inner membrane that
CC drives transmembrane transport and the ATP synthase. Cytochrome c
CC oxidase is the component of the respiratory chain that catalyzes the
CC reduction of oxygen to water. Electrons originating from reduced
CC cytochrome c in the intermembrane space (IMS) are transferred via the
CC dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1
CC to the active site in subunit 1, a binuclear center (BNC) formed by
CC heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2
CC water molecules using 4 electrons from cytochrome c in the IMS and 4
CC protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P13183}.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000250|UniProtKB:P13183}.
CC -!- SUBUNIT: Component of the cytochrome c oxidase (complex IV, CIV), a
CC multisubunit enzyme composed of 14 subunits. The complex is composed of
CC a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in
CC the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A,
CC COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which
CC are encoded in the nuclear genome. The complex exists as a monomer or a
CC dimer and forms supercomplexes (SCs) in the inner mitochondrial
CC membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and
CC ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex
CC III, CIII), resulting in different assemblies (supercomplex
CC SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
CC {ECO:0000250|UniProtKB:P13183}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P13183}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:P13183}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase VIIb family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH35923.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI07856.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAL75946.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF125109; AAL75946.1; ALT_INIT; mRNA.
DR EMBL; BC035923; AAH35923.1; ALT_INIT; mRNA.
DR EMBL; BC107855; AAI07856.1; ALT_INIT; mRNA.
DR CCDS; CCDS3472.2; -.
DR RefSeq; NP_570972.2; NM_130902.2.
DR RefSeq; XP_005248113.1; XM_005248056.4.
DR RefSeq; XP_011511932.1; XM_011513630.2.
DR RefSeq; XP_011511933.1; XM_011513631.2.
DR RefSeq; XP_011511934.1; XM_011513632.2.
DR RefSeq; XP_011511935.1; XM_011513633.2.
DR RefSeq; XP_011511936.1; XM_011513634.2.
DR RefSeq; XP_011511937.1; XM_011513635.2.
DR RefSeq; XP_011511938.1; XM_011513636.1.
DR RefSeq; XP_011511939.1; XM_011513637.2.
DR RefSeq; XP_011511940.1; XM_011513638.2.
DR AlphaFoldDB; Q8TF08; -.
DR BioGRID; 128085; 11.
DR STRING; 9606.ENSP00000379784; -.
DR TCDB; 3.D.4.11.1; the proton-translocating cytochrome oxidase (cox) superfamily.
DR iPTMnet; Q8TF08; -.
DR PhosphoSitePlus; Q8TF08; -.
DR BioMuta; COX7B2; -.
DR DMDM; 229462876; -.
DR MassIVE; Q8TF08; -.
DR PaxDb; Q8TF08; -.
DR PeptideAtlas; Q8TF08; -.
DR PRIDE; Q8TF08; -.
DR Antibodypedia; 55964; 46 antibodies from 15 providers.
DR DNASU; 170712; -.
DR Ensembl; ENST00000355591.8; ENSP00000347799.3; ENSG00000170516.17.
DR Ensembl; ENST00000396533.5; ENSP00000379784.1; ENSG00000170516.17.
DR GeneID; 170712; -.
DR KEGG; hsa:170712; -.
DR MANE-Select; ENST00000355591.8; ENSP00000347799.3; NM_130902.3; NP_570972.2.
DR UCSC; uc003gxf.4; human.
DR CTD; 170712; -.
DR DisGeNET; 170712; -.
DR GeneCards; COX7B2; -.
DR HGNC; HGNC:24381; COX7B2.
DR HPA; ENSG00000170516; Tissue enriched (testis).
DR MIM; 609811; gene.
DR neXtProt; NX_Q8TF08; -.
DR OpenTargets; ENSG00000170516; -.
DR PharmGKB; PA134885922; -.
DR VEuPathDB; HostDB:ENSG00000170516; -.
DR eggNOG; ENOG502S9DG; Eukaryota.
DR GeneTree; ENSGT00390000012178; -.
DR InParanoid; Q8TF08; -.
DR OMA; QIRARQS; -.
DR OrthoDB; 1571716at2759; -.
DR PhylomeDB; Q8TF08; -.
DR TreeFam; TF105068; -.
DR PathwayCommons; Q8TF08; -.
DR UniPathway; UPA00705; -.
DR BioGRID-ORCS; 170712; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; COX7B2; human.
DR GenomeRNAi; 170712; -.
DR Pharos; Q8TF08; Tdark.
DR PRO; PR:Q8TF08; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8TF08; protein.
DR Bgee; ENSG00000170516; Expressed in right testis and 64 other tissues.
DR ExpressionAtlas; Q8TF08; baseline and differential.
DR Genevisible; Q8TF08; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005746; C:mitochondrial respirasome; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0045277; C:respiratory chain complex IV; IBA:GO_Central.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR CDD; cd01403; Cyt_c_Oxidase_VIIb; 1.
DR Gene3D; 4.10.51.10; -; 1.
DR InterPro; IPR008433; Cyt_c_oxidase_suVIIB.
DR InterPro; IPR023272; Cyt_c_oxidase_suVIIB_dom_sf.
DR PANTHER; PTHR16716; PTHR16716; 1.
DR Pfam; PF05392; COX7B; 1.
DR SUPFAM; SSF81423; SSF81423; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:P13183"
FT CHAIN 26..81
FT /note="Cytochrome c oxidase subunit 7B2, mitochondrial"
FT /id="PRO_0000006161"
FT TOPO_DOM 26..33
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:P13183"
FT TRANSMEM 34..60
FT /note="Helical"
FT /evidence="ECO:0000250|UniProtKB:P13183"
FT TOPO_DOM 61..81
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:P13183"
FT VARIANT 27
FT /note="H -> Q (in dbSNP:rs201505906)"
FT /evidence="ECO:0000269|PubMed:15623157"
FT /id="VAR_026231"
SQ SEQUENCE 81 AA; 9077 MW; 3E9769D2EBF42E25 CRC64;
MMFPLARNAL SSLKIQSILQ SMARHSHVKH SPDFHDKYGN AVLASGTAFC VATWVFTATQ
IGIEWNLSPV GRVTPKEWKH Q
