ID   CX9A_CRACE              Reviewed;          59 AA.
AC   G8FZS4;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Crassipeptide cce9a;
DE   AltName: Full=Cce9.1;
DE   Flags: Precursor; Fragment;
OS   Crassispira cerithina (Sea snail) (Turridrupa cerithina).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Turridae; Crassispira.
OX   NCBI_TaxID=1077925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 31-59, SYNTHESIS OF 31-59,
RP   FUNCTION, BIOASSAY, DISULFIDE BOND, AND MASS SPECTROMETRY.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=21939682; DOI=10.1016/j.toxicon.2011.09.001;
RA   Cabang A.B., Imperial J.S., Gajewiak J., Watkins M., Corneli P.S.,
RA   Olivera B.M., Concepcion G.P.;
RT   "Characterization of a venom peptide from a crassispirid gastropod.";
RL   Toxicon 58:672-680(2011).
CC   -!- FUNCTION: Crassispirid snail peptide that induces sleep-like symptoms
CC       in young mice (12 and 14 days) and hyperactivity in older mice (16
CC       days), when intracranially injected. {ECO:0000269|PubMed:21939682}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C).
CC   -!- PTM: Contains 3 disulfide bonds.
CC   -!- MASS SPECTROMETRY: Mass=3204.11; Method=MALDI; Note=monoisotopic.;
CC       Evidence={ECO:0000269|PubMed:21939682};
CC   -!- MISCELLANEOUS: Has no activity on N-methyl-D-aspartate (NMDA)
CC       receptors. {ECO:0000305|PubMed:21939682}.
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DR   EMBL; JN088480; AEO12552.1; -; mRNA.
DR   AlphaFoldDB; G8FZS4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin; Secreted; Toxin.
FT   PROPEP          <1..30
FT                   /evidence="ECO:0000269|PubMed:21939682"
FT                   /id="PRO_0000419831"
FT   PEPTIDE         31..59
FT                   /note="Crassipeptide cce9a"
FT                   /id="PRO_5000814452"
FT   NON_TER         1
SQ   SEQUENCE   59 AA;  6471 MW;  C3006E0494D0297F CRC64;
     ADNHARVAGP RAVASGRYAT EKAFLQMMTR GSCGLPCHEN RRCGWACYCD DGICKPLRV