CXA10_HUMAN
ID CXA10_HUMAN Reviewed; 543 AA.
AC Q969M2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Gap junction alpha-10 protein;
DE AltName: Full=Connexin-62;
DE Short=Cx62;
GN Name=GJA10; Synonyms=CX62;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Houseman M.J., Kelsell D.P., Mueller R.F.;
RT "Isolation and expression of connexin-62: a novel human connexin with high
RT homology to mouse connexin-57 and porcine connexin-60.";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12108537; DOI=10.1515/bc.2002.076;
RA Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M.,
RA Deutsch U., Soehl G.;
RT "Structural and functional diversity of connexin genes in the mouse and
RT human genome.";
RL Biol. Chem. 383:725-737(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12881038; DOI=10.1080/15419060302063;
RA Soehl G., Nielsen P.A., Eiberger J., Willecke K.;
RT "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1,
RT and hCx62 differ from their putative mouse orthologues.";
RL Cell Commun. Adhes. 10:27-36(2003).
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell. Involved in
CC tracer coupling between horizontal cells of the retina. May play a role
CC in the regulation of horizontal cell patterning (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in skeletal muscle and heart.
CC {ECO:0000269|PubMed:12881038}.
CC -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC subfamily. {ECO:0000305}.
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DR EMBL; AF296766; AAK51676.1; -; mRNA.
DR EMBL; AJ414565; CAC93847.1; -; Genomic_DNA.
DR EMBL; AL353692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48537.1; -; Genomic_DNA.
DR CCDS; CCDS5025.1; -.
DR RefSeq; NP_115991.1; NM_032602.1.
DR AlphaFoldDB; Q969M2; -.
DR SMR; Q969M2; -.
DR BioGRID; 124209; 16.
DR IntAct; Q969M2; 3.
DR STRING; 9606.ENSP00000358358; -.
DR BioMuta; GJA10; -.
DR DMDM; 74751723; -.
DR MassIVE; Q969M2; -.
DR PaxDb; Q969M2; -.
DR PeptideAtlas; Q969M2; -.
DR PRIDE; Q969M2; -.
DR ProteomicsDB; 75791; -.
DR Antibodypedia; 56329; 54 antibodies from 12 providers.
DR DNASU; 84694; -.
DR Ensembl; ENST00000369352.1; ENSP00000358358.1; ENSG00000135355.4.
DR Ensembl; ENST00000672086.1; ENSP00000500643.1; ENSG00000288435.1.
DR GeneID; 84694; -.
DR KEGG; hsa:84694; -.
DR MANE-Select; ENST00000369352.1; ENSP00000358358.1; NM_032602.2; NP_115991.1.
DR UCSC; uc011eaa.3; human.
DR CTD; 84694; -.
DR DisGeNET; 84694; -.
DR GeneCards; GJA10; -.
DR HGNC; HGNC:16995; GJA10.
DR HPA; ENSG00000135355; Not detected.
DR MIM; 611924; gene.
DR neXtProt; NX_Q969M2; -.
DR OpenTargets; ENSG00000135355; -.
DR PharmGKB; PA164741581; -.
DR VEuPathDB; HostDB:ENSG00000135355; -.
DR eggNOG; ENOG502QQPH; Eukaryota.
DR GeneTree; ENSGT01050000244914; -.
DR HOGENOM; CLU_037388_1_0_1; -.
DR InParanoid; Q969M2; -.
DR OMA; WEQSQDL; -.
DR OrthoDB; 714519at2759; -.
DR PhylomeDB; Q969M2; -.
DR TreeFam; TF329606; -.
DR PathwayCommons; Q969M2; -.
DR Reactome; R-HSA-112303; Electric Transmission Across Gap Junctions.
DR Reactome; R-HSA-190861; Gap junction assembly.
DR SignaLink; Q969M2; -.
DR BioGRID-ORCS; 84694; 7 hits in 1058 CRISPR screens.
DR ChiTaRS; GJA10; human.
DR GeneWiki; GJA10; -.
DR GenomeRNAi; 84694; -.
DR Pharos; Q969M2; Tdark.
DR PRO; PR:Q969M2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q969M2; protein.
DR Bgee; ENSG00000135355; Expressed in left testis and 2 other tissues.
DR ExpressionAtlas; Q969M2; baseline and differential.
DR Genevisible; Q969M2; HS.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR GO; GO:0007276; P:gamete generation; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..543
FT /note="Gap junction alpha-10 protein"
FT /id="PRO_0000312989"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 306..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 61872 MW; B3115A282957207D CRC64;
MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLRVA AEDVWDDEQS AFACNTRQPG
CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL RAFEKDRQRK KSHLRAQMEN
PDLDLEEQQR IDRELRRLEE QKRIHKVPLK GCLLRTYVLH ILTRSVLEVG FMIGQYILYG
FQMHPLYKCT QPPCPNAVDC FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR
TLYKKSSSEG IEDETGPPFH LKKYSVAQQC MICSSLPERI SPLQANNQQQ VIRVNVPKSK
TMWQIPQPRQ LEVDPSNGKK DWSEKDQHSG QLHVHSPCPW AGSAGNQHLG QQSDHSSFGL
QNTMSQSWLG TTTAPRNCPS FAVGTWEQSQ DPEPSGEPLT DLHSHCRDSE GSMRESGVWI
DRSRPGSRKA SFLSRLLSEK RHLHSDSGSS GSRNSSCLDF PHWENSPSPL PSVTGHRTSM
VRQAALPIME LSQELFHSGC FLFPFFLPGV CMYVCVDREA DGGGDYLWRD KIIHSIHSVK
FNS
