ID   CXA4_BOVIN              Reviewed;         333 AA.
AC   A4IFL1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Gap junction alpha-4 protein;
DE   AltName: Full=Connexin-37;
DE            Short=Cx37;
GN   Name=GJA4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC134629; AAI34630.1; -; mRNA.
DR   RefSeq; NP_001077207.1; NM_001083738.1.
DR   AlphaFoldDB; A4IFL1; -.
DR   SMR; A4IFL1; -.
DR   STRING; 9913.ENSBTAP00000018428; -.
DR   PaxDb; A4IFL1; -.
DR   PRIDE; A4IFL1; -.
DR   Ensembl; ENSBTAT00000018428; ENSBTAP00000018428; ENSBTAG00000013881.
DR   GeneID; 538913; -.
DR   KEGG; bta:538913; -.
DR   CTD; 2701; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013881; -.
DR   VGNC; VGNC:29373; GJA4.
DR   eggNOG; ENOG502QU20; Eukaryota.
DR   GeneTree; ENSGT01050000244914; -.
DR   HOGENOM; CLU_037388_4_2_1; -.
DR   InParanoid; A4IFL1; -.
DR   OMA; KDPHVER; -.
DR   OrthoDB; 903777at2759; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000013881; Expressed in bone marrow and 100 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR002263; Connexin37.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   PRINTS; PR01134; CONNEXINA4.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Gap junction alpha-4 protein"
FT                   /id="PRO_0000313004"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..148
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..207
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        231..333
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          303..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  37499 MW;  10835D6DAD99CDE5 CRC64;
     MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG
     CTNVCYDQAF PISHIRYWVL QFLFVSTPTL VYLGHVIYLS RREERLRQKE GELRALPAKD
     PRVERALASI ERQMAKISVA EDGHLRIRGA LMGTYVASVL CKSVLEAGFL YGQWRLYGWT
     MEPVFVCQRS PCPYLVDCFV SRPTEKTIFI IFMLVVGLIS LVLNLLELAY LLCRCLSRGV
     RARQRQDAPP APGTSSEPYA DQVFFYLPMS EGPSSPPCPT YNGLSSSEQN WANLTTEERL
     ASSRAPLFLD PPPQTGRKSP SRPSSSASKK QYV