ID   CXA4_PIG                Reviewed;         138 AA.
AC   Q29559;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Gap junction alpha-4 protein;
DE   AltName: Full=Connexin-37;
DE            Short=Cx37;
DE   Flags: Fragment;
GN   Name=GJA4;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Large white X Duroc; TISSUE=Aortic endothelium;
RX   PubMed=8832399; DOI=10.1242/jcs.109.7.1765;
RA   Carter T.D., Cen X.Y., Carlile G., Kalapothakis E., Ogden D., Evans W.H.;
RT   "Porcine aortic endothelial gap junctions: identification and permeation by
RT   caged InsP3.";
RL   J. Cell Sci. 109:1765-1773(1996).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
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DR   EMBL; X86024; CAA60019.1; -; mRNA.
DR   AlphaFoldDB; Q29559; -.
DR   SMR; Q29559; -.
DR   InParanoid; Q29559; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           <1..>138
FT                   /note="Gap junction alpha-4 protein"
FT                   /id="PRO_0000057816"
FT   TOPO_DOM        <1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        40..74
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..>138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         138
SQ   SEQUENCE   138 AA;  15836 MW;  9298B6C67884C222 CRC64;
     DWGFLEKLLD QVQEHSTVVG KIWLTVLFIF RILILGLAGE SVWGDEQSDF ECNTAQPGCT
     NVCYDQAFPI SHIPYWVLQF LFVSTPTLVY LGHVIYLSRR EERLRQKEGE LRALPDKDPR
     VERALAGIER QMAKISVA