ID   CXA4_XENLA              Reviewed;         352 AA.
AC   P51914;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Gap junction alpha-4 protein;
DE   AltName: Full=Connexin-41;
DE            Short=Cx41;
GN   Name=gja4; Synonyms=cx41;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Ovary;
RX   PubMed=8562053; DOI=10.1002/mrd.1080420103;
RA   Yoshizaki G., Patino R.;
RT   "Molecular cloning, tissue distribution, and hormonal control in the ovary
RT   of Cx41 mRNA, a novel Xenopus connexin gene transcript.";
RL   Mol. Reprod. Dev. 42:7-18(1995).
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC       junction, gap junction.
CC   -!- TISSUE SPECIFICITY: Expressed in ovarian somatic cells, heart, leg
CC       muscle, liver and eye but not in brain. {ECO:0000269|PubMed:8562053}.
CC   -!- DEVELOPMENTAL STAGE: Maternal protein whose levels decrease in late
CC       stages of oocyte maturation. {ECO:0000269|PubMed:8562053}.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U26256; AAA93235.1; -; mRNA.
DR   RefSeq; NP_001165443.1; NM_001171972.1.
DR   AlphaFoldDB; P51914; -.
DR   SMR; P51914; -.
DR   GeneID; 100335149; -.
DR   KEGG; xla:100335149; -.
DR   CTD; 100335149; -.
DR   Xenbase; XB-GENE-6464391; gja4.L.
DR   OMA; KDPHVER; -.
DR   OrthoDB; 903777at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 100335149; Expressed in lung and 14 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007154; P:cell communication; IEA:InterPro.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR034634; Connexin_C.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   SUPFAM; SSF118220; SSF118220; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..352
FT                   /note="Gap junction alpha-4 protein"
FT                   /id="PRO_0000057845"
FT   TOPO_DOM        2..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          332..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  40633 MW;  016023F7483D6D90 CRC64;
     MGDWEFLEKL LDQVQEHSTS IGKIWLMVLF IFRILILGLA GESVWGDEQS DFTCNTEQPG
     CTNVCYDKAF PISHVRYWVL QFLFVSTPTL FYLGHVIYLS RKEEKLKQKE SELRALDDKE
     QVEQAIAIIE KKKLKLYIQE DGTVKIKGAL MYTYLTSVIF KSIFEAGFLL GQWYLYGFVM
     TPIYVCERVP CPHKVDCFVS RPMEKTIFII FMLVVSLISL FLNVLELIHL ICKSMIHALK
     KYSQYIPANR YPKNEDTYPE KTSETATAPF QDKSYIYLPM NENISYPQYK MPNEQNWVNF
     NTEQQLAISG NTQSPLGHYS LSAFLPVSPK THSTVEKAST RASSSASKKQ YV