ID   CXA4_XENTR              Reviewed;         352 AA.
AC   Q0V990;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Gap junction alpha-4 protein;
DE   AltName: Full=Connexin-41;
DE            Short=Cx41;
GN   Name=gja4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC       pairs of transmembrane channels, the connexons, through which materials
CC       of low MW diffuse from one cell to a neighboring cell. {ECO:0000250}.
CC   -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Cell junction, gap junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121698; AAI21699.1; -; mRNA.
DR   RefSeq; NP_001072904.1; NM_001079436.1.
DR   AlphaFoldDB; Q0V990; -.
DR   SMR; Q0V990; -.
DR   STRING; 8364.ENSXETP00000056254; -.
DR   PaxDb; Q0V990; -.
DR   DNASU; 780366; -.
DR   Ensembl; ENSXETT00000056254; ENSXETP00000056254; ENSXETG00000026789.
DR   GeneID; 780366; -.
DR   KEGG; xtr:780366; -.
DR   CTD; 2701; -.
DR   Xenbase; XB-GENE-977956; gja4.
DR   eggNOG; ENOG502QU20; Eukaryota.
DR   HOGENOM; CLU_037388_4_2_1; -.
DR   InParanoid; Q0V990; -.
DR   OMA; KDPHVER; -.
DR   OrthoDB; 903777at2759; -.
DR   PhylomeDB; Q0V990; -.
DR   TreeFam; TF329606; -.
DR   Reactome; R-XTR-190861; Gap junction assembly.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026789; Expressed in skeletal muscle tissue and 11 other tissues.
DR   GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR   Gene3D; 1.20.1440.80; -; 1.
DR   InterPro; IPR000500; Connexin.
DR   InterPro; IPR034634; Connexin_C.
DR   InterPro; IPR019570; Connexin_CCC.
DR   InterPro; IPR017990; Connexin_CS.
DR   InterPro; IPR013092; Connexin_N.
DR   InterPro; IPR038359; Connexin_N_sf.
DR   PANTHER; PTHR11984; PTHR11984; 1.
DR   Pfam; PF00029; Connexin; 1.
DR   PRINTS; PR00206; CONNEXIN.
DR   SMART; SM00037; CNX; 1.
DR   SMART; SM01089; Connexin_CCC; 1.
DR   SUPFAM; SSF118220; SSF118220; 1.
DR   PROSITE; PS00407; CONNEXINS_1; 1.
DR   PROSITE; PS00408; CONNEXINS_2; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Gap junction; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..352
FT                   /note="Gap junction alpha-4 protein"
FT                   /id="PRO_0000313012"
FT   TOPO_DOM        2..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..76
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        100..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..208
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        232..352
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          330..352
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  40626 MW;  6FB5A685F94CD9DD CRC64;
     MGDWEFLEKL LDQVQEHSTS IGKIWLMVLF IFRILILGLA GESVWGDEQS DFICNTEQPG
     CTNVCYDKAF PISHVRYWVL QFLFVSTPTL FYLGHVIYLS RREEKLKQKE SELRALDDKE
     QVEQAIAIIE KKKMKLYIQE DGTVKIKGAL MCTYLTSVIF KSLFEAGFLL GQWYLYGFVM
     TPIYVCERVP CPHKVDCFVS RPMEKTIFIV FMLVVSLISL FLNVLELIHL VCKSMIDTLK
     KYSPYVPPNR YPKNEDTYPE KTSETATAPF QDKSYIYLPM NDNISYPQYK MPNEQNWANF
     NTEHQLAISG NNQSPLGHYS LSAFVPVPPK THSTMEKPST RASSSASKKQ YV