CXA5_CANLF
ID CXA5_CANLF Reviewed; 358 AA.
AC P33725; A5YV78; Q0Q0E3; Q56UX8;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 4.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Gap junction alpha-5 protein;
DE AltName: Full=Connexin-40;
DE Short=Cx40;
GN Name=GJA5;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1310450; DOI=10.1161/01.res.70.2.438;
RA Kanter H.L., Saffitz J.E., Beyer E.C.;
RT "Cardiac myocytes express multiple gap junction proteins.";
RL Circ. Res. 70:438-444(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hyun C., Kang M., Filippich L.J.;
RT "Isolation and comparison of canine connexin 40, 43 and 45.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hyun C., Lee S.-A., Lee S.-G.;
RT "Canine Cx40 gene screening.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hyun C., Lee S.-A.;
RT "Isolation and characterization of canine connexin 40 gene.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell
CC junction, gap junction.
CC -!- SIMILARITY: Belongs to the connexin family. Alpha-type (group II)
CC subfamily. {ECO:0000305}.
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DR EMBL; M81347; AAA30838.1; -; Genomic_DNA.
DR EMBL; AY567709; AAT10275.1; -; mRNA.
DR EMBL; DQ666281; ABG75571.1; -; mRNA.
DR EMBL; EF589114; ABQ97017.1; -; mRNA.
DR PIR; A49024; A49024.
DR RefSeq; NP_001017442.2; NM_001017442.2.
DR AlphaFoldDB; P33725; -.
DR SMR; P33725; -.
DR STRING; 9612.ENSCAFP00000016302; -.
DR PaxDb; P33725; -.
DR Ensembl; ENSCAFT00030021096; ENSCAFP00030018393; ENSCAFG00030011400.
DR Ensembl; ENSCAFT00040032388; ENSCAFP00040028174; ENSCAFG00040017521.
DR Ensembl; ENSCAFT00845017555; ENSCAFP00845013664; ENSCAFG00845009988.
DR GeneID; 483155; -.
DR KEGG; cfa:483155; -.
DR CTD; 2702; -.
DR VEuPathDB; HostDB:ENSCAFG00845009988; -.
DR eggNOG; ENOG502QW11; Eukaryota.
DR GeneTree; ENSGT01050000244864; -.
DR HOGENOM; CLU_037388_0_0_1; -.
DR InParanoid; P33725; -.
DR OMA; FIHIHYG; -.
DR OrthoDB; 992551at2759; -.
DR TreeFam; TF329606; -.
DR Reactome; R-CFA-190861; Gap junction assembly.
DR Proteomes; UP000002254; Chromosome 17.
DR Bgee; ENSCAFG00000011069; Expressed in right cardiac atrium and 45 other tissues.
DR GO; GO:0005922; C:connexin complex; IDA:BHF-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0005243; F:gap junction channel activity; IBA:GO_Central.
DR GO; GO:0086076; F:gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling; IEA:Ensembl.
DR GO; GO:0086077; F:gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling; IEA:Ensembl.
DR GO; GO:0086078; F:gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling; IEA:Ensembl.
DR GO; GO:0055077; F:gap junction hemi-channel activity; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0048844; P:artery morphogenesis; IEA:Ensembl.
DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl.
DR GO; GO:0003294; P:atrial ventricular junction remodeling; IEA:Ensembl.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:Ensembl.
DR GO; GO:0003161; P:cardiac conduction system development; IEA:Ensembl.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0035922; P:foramen ovale closure; IEA:Ensembl.
DR GO; GO:0016264; P:gap junction assembly; IEA:Ensembl.
DR GO; GO:0003174; P:mitral valve development; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
DR GO; GO:0003193; P:pulmonary valve formation; IEA:Ensembl.
DR GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR GO; GO:0098905; P:regulation of bundle of His cell action potential; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:1900825; P:regulation of membrane depolarization during cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0098906; P:regulation of Purkinje myocyte action potential; IEA:Ensembl.
DR GO; GO:1900133; P:regulation of renin secretion into blood stream; IEA:Ensembl.
DR GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR GO; GO:0003071; P:renal system process involved in regulation of systemic arterial blood pressure; IEA:Ensembl.
DR GO; GO:0086015; P:SA node cell action potential; IEA:Ensembl.
DR GO; GO:0003284; P:septum primum development; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; -; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR002264; Connexin40.
DR InterPro; IPR034634; Connexin_C.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR InterPro; IPR031862; Cx40_C.
DR PANTHER; PTHR11984; PTHR11984; 1.
DR PANTHER; PTHR11984:SF13; PTHR11984:SF13; 1.
DR Pfam; PF00029; Connexin; 1.
DR Pfam; PF16791; Connexin40_C; 1.
DR PRINTS; PR00206; CONNEXIN.
DR PRINTS; PR01135; CONNEXINA5.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR SUPFAM; SSF118220; SSF118220; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..358
FT /note="Gap junction alpha-5 protein"
FT /id="PRO_0000057818"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..76
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 318..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 353
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P28234"
FT MOD_RES 357
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P28234"
FT CONFLICT 107..110
FT /note="KLRE -> NVRK (in Ref. 1; AAA30838)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="Missing (in Ref. 1; AAA30838)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="E -> K (in Ref. 1; AAA30838)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="H -> N (in Ref. 1; AAA30838)"
FT /evidence="ECO:0000305"
FT CONFLICT 330
FT /note="G -> S (in Ref. 2; AAT10275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 358 AA; 40142 MW; 92B307D5DF9ED920 CRC64;
MGDWSFLGEF LEEVHKHSTV IGKVWLTVLF IFRMLVLGTA AESSWGDEQA DFQCDTMQPG
CGNVCYDQAF PISHIRYWVL QIIFVSTPSL VYMGHAMHTV RMQEKRKLRE AERAKEARGA
GSYEYPVAEK AELSCWEEVN GRIVLQGTLL NTYVCSILIR TTMEVAFIVG QYLLYGIFLD
TLHVCRRSPC PHPVNCYVSR PTEKNVFIVF MLAVAALSLF LSLAELYHLG WKKLRQRFVK
SGQGMAECQL PGPSAGIVQN CTPPPDFNQC LENGPGGKFF NPFSNKMASQ QNTDNLATEQ
VQGQEPIPGE GFIHIRYAQK PEVPNGASPG HRLPHGYQSD KRRLSKASSK ARSDDLSV
